| SP | Wheeler, Z.Wheeler, Zack # | Sasquatch | R | 129.0 | 31 | 31 | 18 | 6 | 3.62 | .278 | 1.11 | 8.0 | 2.0 | 9.9 | 204.0 | 181 | 82 | 82 | 24 | 45 | 224 | 1 | 0 | 0 | 1 | 18 | 10 | 2 | 3.14 |
| CL | Leclerc, J.Leclerc, Jose † | Pointers | R | 129.0 | 72 | 0 | 3 | 3 | 2.30 | .299 | 1.25 | 6.0 | 5.4 | 10.2 | 74.1 | 49 | 20 | 19 | 2 | 44 | 84 | 0 | 38 | 4 | 0 | 0 | 2 | 0 | 2.95 |
| SP | Buchholz, C.Buchholz, Clay † # | Spiders | R | 121.0 | 31 | 31 | 16 | 5 | 3.55 | .275 | 1.11 | 7.2 | 2.8 | 6.9 | 213.0 | 171 | 84 | 84 | 28 | 66 | 163 | 3 | 0 | 0 | 1 | 21 | 5 | 1 | 4.18 |
| CL | Treinen, B.Treinen, Blake † | Lancers | R | 117.5 | 69 | 0 | 2 | 3 | 2.45 | .276 | 1.09 | 6.5 | 3.3 | 10.5 | 73.1 | 53 | 20 | 20 | 8 | 27 | 85 | 0 | 37 | 6 | 0 | 0 | 4 | 3 | 3.37 |
| SP | Buehler, W.Buehler, Walker | Spiders | R | 115.0 | 32 | 32 | 14 | 9 | 3.00 | .273 | 1.09 | 7.4 | 2.4 | 9.3 | 207.1 | 171 | 70 | 69 | 15 | 56 | 215 | 0 | 0 | 0 | 0 | 21 | 7 | 5 | 2.78 |
| SP | Kluber, C.Kluber, Corey # | Pointers | R | 107.0 | 31 | 31 | 14 | 7 | 3.55 | .313 | 1.31 | 9.5 | 2.4 | 10.0 | 205.1 | 216 | 84 | 81 | 14 | 54 | 227 | 1 | 0 | 0 | 0 | 20 | 10 | 4 | 2.61 |
| RP | Ottavino, A.Ottavino, Adam † | Sloths | R | 104.5 | 82 | 0 | 10 | 0 | 2.68 | .289 | 1.19 | 6.9 | 3.8 | 10.6 | 117.1 | 90 | 36 | 35 | 12 | 50 | 138 | 0 | 7 | 4 | 0 | 0 | 3 | 1 | 3.33 |