| SP | Scherzer, M.Scherzer, Max † | Lancers | R | 144.0 | 28 | 28 | 16 | 2 | 2.83 | .267 | 1.06 | 7.3 | 2.3 | 10.3 | 194.1 | 157 | 63 | 61 | 22 | 49 | 223 | 3 | 0 | 0 | 1 | 19 | 6 | 1 | 3.03 |
| RP | Dominguez, S.Dominguez, Seranthony † | Serpents | R | 131.0 | 86 | 0 | 17 | 3 | 2.61 | .311 | 1.31 | 6.2 | 5.7 | 9.2 | 117.1 | 80 | 34 | 34 | 11 | 74 | 120 | 0 | 6 | 4 | 0 | 0 | 5 | 16 | 4.20 |
| SP | deGrom, J.deGrom, Jacob † # | Spiders | R | 104.0 | 28 | 28 | 14 | 4 | 3.73 | .291 | 1.19 | 8.3 | 2.4 | 10.7 | 178.2 | 165 | 74 | 74 | 22 | 48 | 212 | 1 | 0 | 0 | 0 | 19 | 7 | 2 | 3.15 |
| SP | Kluber, C.Kluber, Corey † | Horses | R | 103.0 | 27 | 27 | 13 | 8 | 3.23 | .295 | 1.24 | 8.8 | 2.4 | 10.0 | 184.0 | 179 | 81 | 66 | 20 | 49 | 204 | 1 | 0 | 0 | 0 | 20 | 3 | 3 | 3.04 |
| SP | Corbin, P.Corbin, Patrick | Tigers | L | 100.0 | 28 | 28 | 12 | 7 | 3.23 | .280 | 1.16 | 8.0 | 2.5 | 10.4 | 186.2 | 165 | 73 | 67 | 12 | 51 | 215 | 1 | 0 | 0 | 0 | 21 | 2 | 2 | 2.38 |
| SP | Teheran, J.Teheran, Julio | Lancers | R | 93.0 | 27 | 27 | 11 | 4 | 2.99 | .308 | 1.30 | 7.3 | 4.4 | 8.4 | 156.1 | 127 | 55 | 52 | 8 | 77 | 145 | 0 | 0 | 0 | 0 | 14 | 5 | 4 | 3.38 |
| CL | Leclerc, J.Leclerc, Jose † | Bobcats | R | 87.5 | 53 | 0 | 6 | 7 | 3.42 | .265 | 1.08 | 5.4 | 4.5 | 10.7 | 52.2 | 31 | 20 | 20 | 4 | 26 | 62 | 0 | 25 | 4 | 0 | 0 | 0 | 1 | 3.12 |