| SP | Kershaw, C.Kershaw, Clayton † | First Pick | L | 145.0 | 37 | 37 | 18 | 15 | 3.40 | .276 | 1.13 | 8.1 | 2.1 | 10.0 | 278.1 | 251 | 109 | 105 | 36 | 64 | 309 | 9 | 0 | 0 | 2 | 24 | 4 | 6 | 3.19 |
| SP | deGrom, J.deGrom, Jacob # $ | Red Sox | R | 142.0 | 35 | 35 | 17 | 8 | 2.92 | .251 | 0.99 | 6.8 | 2.2 | 10.4 | 224.2 | 168 | 75 | 73 | 38 | 54 | 258 | 1 | 0 | 0 | 0 | 26 | 4 | 0 | 3.68 |
| CL | Doolittle, S.Doolittle, Sean † | Red Sox | L | 140.0 | 70 | 0 | 8 | 7 | 3.39 | .281 | 1.17 | 8.0 | 2.6 | 10.3 | 74.1 | 66 | 28 | 28 | 15 | 21 | 85 | 0 | 40 | 6 | 0 | 0 | 0 | 1 | 4.19 |
| RP | Kimbrel, C.Kimbrel, Craig † | Warriors | R | 132.0 | 92 | 0 | 14 | 5 | 2.02 | .249 | 0.98 | 5.3 | 3.6 | 11.6 | 120.1 | 70 | 28 | 27 | 11 | 48 | 155 | 0 | 10 | 4 | 0 | 0 | 2 | 9 | 2.86 |
| SP | Tanana, F.Tanana, Frank # $$ | Trojans | L | 127.0 | 29 | 29 | 17 | 6 | 3.90 | .293 | 1.23 | 7.7 | 3.4 | 7.2 | 224.0 | 191 | 103 | 97 | 29 | 84 | 178 | 12 | 0 | 0 | 1 | 18 | 4 | 4 | 4.27 |
| CL | Street, H.Street, Huston † $ | CRACKERS | R | 114.0 | 64 | 0 | 5 | 4 | 2.90 | .270 | 1.11 | 6.6 | 3.4 | 9.0 | 71.1 | 52 | 23 | 23 | 10 | 27 | 71 | 0 | 32 | 4 | 0 | 0 | 0 | 1 | 3.97 |
| RP | Benoit, J.Benoit, Joaquin | Sharks | R | 113.0 | 107 | 0 | 9 | 1 | 2.75 | .258 | 1.00 | 6.0 | 3.0 | 9.4 | 154.0 | 102 | 48 | 47 | 17 | 52 | 161 | 0 | 8 | 1 | 0 | 0 | 7 | 4 | 3.49 |