| SP | Maddux, G.Maddux, Greg † $ | CRACKERS | R | 186.0 | 37 | 37 | 21 | 8 | 3.17 | .266 | 1.07 | 7.3 | 2.4 | 7.0 | 303.2 | 246 | 108 | 107 | 34 | 80 | 237 | 14 | 0 | 0 | 3 | 25 | 4 | 2 | 3.73 |
| SP | Kluber, C.Kluber, Corey † # $$ | Dragon | R | 168.0 | 36 | 36 | 18 | 15 | 3.20 | .257 | 1.01 | 6.9 | 2.2 | 9.4 | 298.1 | 230 | 108 | 106 | 35 | 72 | 311 | 20 | 0 | 0 | 4 | 22 | 8 | 1 | 3.24 |
| CL | Feliz, N.Feliz, Neftali † $$ | Grizzlies | R | 151.5 | 68 | 0 | 9 | 5 | 3.10 | .268 | 1.07 | 5.8 | 3.9 | 9.9 | 78.1 | 50 | 29 | 27 | 14 | 34 | 86 | 0 | 39 | 4 | 0 | 0 | 2 | 0 | 4.51 |
| SP | Kershaw, C.Kershaw, Clayton | Warriors | L | 145.0 | 36 | 36 | 16 | 16 | 3.18 | .238 | 0.91 | 6.7 | 1.5 | 9.5 | 280.0 | 208 | 99 | 99 | 38 | 46 | 294 | 13 | 0 | 0 | 4 | 23 | 8 | 7 | 3.24 |
| SP | Clemens, R.Clemens, Roger | Grizzlies | R | 132.0 | 33 | 33 | 19 | 11 | 3.65 | .281 | 1.15 | 7.5 | 2.8 | 6.8 | 241.2 | 202 | 101 | 98 | 42 | 75 | 182 | 9 | 0 | 0 | 0 | 21 | 6 | 4 | 4.76 |
| SP | Santana, J.Santana, Johan $$ | Red Sox | L | 126.0 | 36 | 36 | 18 | 8 | 3.78 | .299 | 1.27 | 8.3 | 3.1 | 9.0 | 226.1 | 208 | 97 | 95 | 30 | 79 | 227 | 3 | 0 | 0 | 1 | 21 | 2 | 5 | 3.79 |
| SP | deGrom, J.deGrom, Jacob $$ | Trojans | R | 125.0 | 34 | 34 | 16 | 11 | 3.18 | .272 | 1.10 | 7.4 | 2.5 | 10.8 | 226.1 | 185 | 83 | 80 | 23 | 64 | 271 | 0 | 0 | 0 | 0 | 26 | 5 | 0 | 2.84 |
| SP | Johnson, R.Johnson, Randy | Warriors | L | 124.0 | 34 | 34 | 17 | 13 | 3.60 | .277 | 1.12 | 7.1 | 3.0 | 8.6 | 247.1 | 195 | 103 | 99 | 41 | 81 | 236 | 7 | 0 | 0 | 1 | 22 | 8 | 3 | 4.33 |