| CL | Doolittle, S.Doolittle, Sean † | Bombers | L | 127.5 | 50 | 0 | 7 | 4 | 1.84 | .226 | 0.86 | 5.4 | 2.4 | 10.2 | 53.2 | 32 | 11 | 11 | 5 | 14 | 60 | 0 | 31 | 0 | 0 | 0 | 1 | 1 | 2.81 |
| CL | Chapman, A.Chapman, Aroldis † | Mets | L | 122.0 | 65 | 0 | 5 | 4 | 2.48 | .259 | 1.03 | 5.6 | 3.8 | 11.0 | 72.2 | 45 | 20 | 20 | 3 | 30 | 88 | 0 | 32 | 2 | 0 | 0 | 1 | 1 | 2.39 |
| CL | Jansen, K.Jansen, Kenley † | Bucs | R | 111.0 | 53 | 0 | 4 | 6 | 2.55 | .293 | 1.23 | 8.0 | 3.1 | 11.9 | 53.0 | 47 | 15 | 15 | 5 | 18 | 70 | 0 | 34 | 1 | 0 | 0 | 1 | 0 | 2.66 |
| SP | Cueto, J.Cueto, Johnny † # | Horses | R | 110.0 | 27 | 27 | 15 | 7 | 3.84 | .281 | 1.14 | 8.0 | 2.3 | 8.1 | 199.0 | 177 | 88 | 85 | 24 | 50 | 179 | 9 | 0 | 0 | 1 | 16 | 6 | 2 | 3.61 |
| SP | Verlander, J.Verlander, Justin | Pointers | R | 103.0 | 28 | 28 | 15 | 9 | 3.54 | .299 | 1.25 | 8.8 | 2.5 | 9.7 | 180.2 | 175 | 74 | 71 | 21 | 50 | 193 | 1 | 0 | 0 | 0 | 18 | 6 | 3 | 3.31 |
| SP | Buehler, W.Buehler, Walker | Bucs | R | 96.0 | 25 | 25 | 15 | 4 | 3.93 | .307 | 1.31 | 8.7 | 3.2 | 8.6 | 151.1 | 146 | 66 | 66 | 17 | 53 | 144 | 0 | 0 | 0 | 0 | 12 | 2 | 2 | 3.65 |
| SP | Scherzer, M.Scherzer, Max # | Crabs | R | 89.0 | 28 | 28 | 11 | 9 | 3.69 | .287 | 1.16 | 7.5 | 2.9 | 9.9 | 192.2 | 161 | 79 | 79 | 23 | 62 | 212 | 5 | 0 | 0 | 3 | 15 | 10 | 3 | 3.47 |