| CL | Doolittle, S.Doolittle, Sean † | Bombers | L | 127.5 | 50 | 0 | 7 | 4 | 1.84 | .226 | 0.86 | 5.4 | 2.4 | 10.2 | 53.2 | 32 | 11 | 11 | 5 | 14 | 60 | 0 | 31 | 0 | 0 | 0 | 1 | 1 | 2.81 |
| CL | Chapman, A.Chapman, Aroldis † | Mets | L | 118.5 | 64 | 0 | 5 | 4 | 2.51 | .259 | 1.03 | 5.6 | 3.8 | 10.9 | 71.2 | 44 | 20 | 20 | 3 | 30 | 86 | 0 | 31 | 2 | 0 | 0 | 1 | 1 | 2.44 |
| CL | Jansen, K.Jansen, Kenley † | Bucs | R | 111.0 | 53 | 0 | 4 | 6 | 2.55 | .293 | 1.23 | 8.0 | 3.1 | 11.9 | 53.0 | 47 | 15 | 15 | 5 | 18 | 70 | 0 | 34 | 1 | 0 | 0 | 1 | 0 | 2.66 |
| SP | Cueto, J.Cueto, Johnny † # | Horses | R | 110.0 | 26 | 26 | 15 | 7 | 3.81 | .278 | 1.12 | 7.9 | 2.2 | 8.1 | 191.1 | 168 | 84 | 81 | 22 | 47 | 171 | 9 | 0 | 0 | 1 | 16 | 6 | 2 | 3.54 |
| SP | Buehler, W.Buehler, Walker | Bucs | R | 96.0 | 25 | 25 | 15 | 4 | 3.93 | .307 | 1.31 | 8.7 | 3.2 | 8.6 | 151.1 | 146 | 66 | 66 | 17 | 53 | 144 | 0 | 0 | 0 | 0 | 12 | 2 | 2 | 3.65 |
| SP | Verlander, J.Verlander, Justin | Pointers | R | 92.0 | 27 | 27 | 14 | 9 | 3.70 | .305 | 1.28 | 9.0 | 2.6 | 9.7 | 172.2 | 172 | 74 | 71 | 21 | 49 | 185 | 1 | 0 | 0 | 0 | 17 | 6 | 3 | 3.40 |
| SP | Arrieta, J.Arrieta, Jake # | Cavemen | R | 89.0 | 28 | 28 | 11 | 12 | 3.43 | .268 | 1.06 | 7.3 | 2.3 | 9.4 | 202.0 | 163 | 78 | 77 | 19 | 52 | 212 | 5 | 0 | 0 | 1 | 16 | 7 | 3 | 3.00 |