| SP | Kershaw, C.Kershaw, Clayton | Walnut Pickers | L | 159.0 | 37 | 37 | 17 | 12 | 2.90 | .263 | 1.05 | 8.0 | 1.5 | 10.2 | 276.2 | 246 | 101 | 89 | 32 | 45 | 313 | 6 | 0 | 0 | 2 | 25 | 5 | 6 | 2.78 |
| CL | Workman, B.Workman, Brandon † | Walnut Pickers | R | 156.5 | 80 | 0 | 6 | 7 | 1.94 | .286 | 1.15 | 5.1 | 5.3 | 11.7 | 83.1 | 47 | 19 | 18 | 5 | 49 | 108 | 0 | 43 | 4 | 0 | 0 | 4 | 2 | 3.10 |
| SP | Greinke, Z.Greinke, Zack † | Shark-nados | R | 134.0 | 35 | 35 | 19 | 12 | 3.66 | .288 | 1.19 | 8.4 | 2.3 | 7.4 | 255.2 | 237 | 106 | 104 | 33 | 66 | 210 | 6 | 0 | 0 | 3 | 21 | 8 | 4 | 3.91 |
| SP | Arrieta, J.Arrieta, Jake † # | Spiders | R | 134.0 | 34 | 34 | 16 | 11 | 3.14 | .285 | 1.18 | 8.2 | 2.4 | 9.9 | 235.1 | 215 | 86 | 82 | 17 | 62 | 259 | 5 | 0 | 0 | 2 | 24 | 5 | 5 | 2.59 |
| CL | Kimbrel, C.Kimbrel, Craig † | Tornado | R | 134.0 | 71 | 0 | 6 | 4 | 2.83 | .252 | 1.01 | 7.0 | 2.1 | 10.8 | 76.1 | 59 | 24 | 24 | 10 | 18 | 91 | 0 | 36 | 3 | 0 | 0 | 0 | 2 | 3.03 |
| SP | deGrom, J.deGrom, Jacob † | BBCORioles | R | 110.0 | 34 | 34 | 15 | 9 | 3.77 | .296 | 1.22 | 8.7 | 2.3 | 9.5 | 217.0 | 209 | 94 | 91 | 29 | 56 | 229 | 3 | 0 | 0 | 2 | 19 | 9 | 1 | 3.53 |
| SP | Buehler, W.Buehler, Walker | Shark-nados | R | 108.0 | 34 | 34 | 15 | 5 | 3.92 | .293 | 1.22 | 7.8 | 3.2 | 10.1 | 208.2 | 181 | 91 | 91 | 30 | 74 | 233 | 0 | 0 | 0 | 0 | 19 | 5 | 4 | 3.77 |
| SP | Kluber, C.Kluber, Corey † # | Gorillas | R | 108.0 | 34 | 34 | 12 | 15 | 3.47 | .277 | 1.14 | 7.9 | 2.4 | 10.6 | 254.0 | 222 | 105 | 98 | 31 | 68 | 299 | 8 | 0 | 0 | 3 | 21 | 2 | 6 | 3.06 |
| SP | Hernandez, F.Hernandez, Felix | Lions | R | 104.0 | 34 | 34 | 13 | 10 | 3.79 | .294 | 1.22 | 8.5 | 2.5 | 9.2 | 233.0 | 221 | 112 | 98 | 27 | 64 | 237 | 8 | 0 | 0 | 1 | 22 | 6 | 5 | 3.37 |