| CL | Eckersley, D.Eckersley, Dennis † | Mustangs | R | 159.0 | 63 | 0 | 9 | 2 | 2.51 | .233 | 0.88 | 6.2 | 1.7 | 7.7 | 68.0 | 47 | 19 | 19 | 7 | 13 | 58 | 0 | 40 | 4 | 0 | 0 | 2 | 0 | 3.29 |
| SP | Maddux, G.Maddux, Greg † # | Cannonballs | R | 129.0 | 26 | 26 | 16 | 6 | 3.61 | .263 | 1.04 | 7.8 | 1.7 | 6.3 | 209.2 | 180 | 88 | 84 | 27 | 39 | 147 | 15 | 0 | 0 | 2 | 15 | 5 | 2 | 3.90 |
| SP | Kershaw, C.Kershaw, Clayton | Militia | L | 107.0 | 27 | 27 | 11 | 10 | 2.79 | .255 | 0.98 | 7.1 | 1.7 | 8.9 | 206.1 | 162 | 64 | 64 | 22 | 40 | 203 | 4 | 0 | 0 | 2 | 20 | 10 | 3 | 3.15 |
| SP | Greinke, Z.Greinke, Zack † | Mud Skippers | R | 104.0 | 27 | 27 | 14 | 5 | 3.50 | .285 | 1.17 | 7.8 | 2.7 | 7.2 | 187.2 | 163 | 74 | 73 | 16 | 57 | 149 | 2 | 0 | 0 | 0 | 17 | 4 | 0 | 3.50 |
| SP | Saberhagen, B.Saberhagen, Bret | Mustangs | R | 93.0 | 25 | 25 | 14 | 4 | 4.13 | .310 | 1.33 | 9.3 | 2.8 | 6.2 | 176.2 | 181 | 81 | 81 | 27 | 54 | 121 | 4 | 0 | 0 | 1 | 13 | 3 | 5 | 4.59 |
| CL | Saito, T.Saito, Takashi † | Militia | R | 91.5 | 48 | 0 | 1 | 4 | 1.44 | .227 | 0.84 | 3.8 | 3.8 | 9.2 | 50.0 | 21 | 8 | 8 | 2 | 21 | 51 | 0 | 29 | 1 | 0 | 0 | 2 | 0 | 2.86 |
| SP | Verlander, J.Verlander, Justin † | Lions | R | 89.0 | 27 | 27 | 12 | 12 | 3.24 | .290 | 1.20 | 8.0 | 2.8 | 9.1 | 189.0 | 168 | 74 | 68 | 24 | 59 | 191 | 1 | 0 | 0 | 0 | 19 | 5 | 3 | 3.65 |