| SP | Duchscherer, J.Duchscherer, Justin † | Giants | R | 89.0 | 22 | 22 | 12 | 4 | 3.36 | .309 | 1.31 | 8.3 | 3.5 | 6.3 | 150.0 | 138 | 63 | 56 | 16 | 59 | 105 | 1 | 0 | 0 | 1 | 16 | 4 | 5 | 4.25 |
| SP | Buehrle, M.Buehrle, Mark † # | Snakes | L | 88.0 | 22 | 22 | 12 | 4 | 3.93 | .291 | 1.21 | 8.4 | 2.5 | 6.7 | 155.2 | 145 | 69 | 68 | 18 | 43 | 115 | 6 | 0 | 0 | 3 | 13 | 4 | 3 | 3.94 |
| SP | Lincecum, T.Lincecum, Tim # | Serpents | R | 81.0 | 23 | 23 | 11 | 8 | 3.68 | .278 | 1.11 | 8.0 | 2.0 | 9.4 | 164.0 | 146 | 68 | 67 | 21 | 36 | 172 | 3 | 0 | 0 | 1 | 13 | 7 | 9 | 3.35 |
| CL | Rivera, M.Rivera, Mariano † | Tanks | R | 81.0 | 44 | 0 | 2 | 6 | 1.85 | .274 | 1.09 | 8.1 | 1.9 | 10.1 | 48.2 | 43 | 10 | 10 | 2 | 10 | 54 | 0 | 26 | 2 | 0 | 0 | 2 | 0 | 2.04 |
| SP | Johnson, R.Johnson, Randy | Machine | L | 77.0 | 21 | 21 | 12 | 6 | 4.09 | .298 | 1.23 | 8.1 | 3.0 | 10.5 | 134.1 | 120 | 66 | 61 | 18 | 45 | 156 | 2 | 0 | 0 | 1 | 10 | 6 | 2 | 3.56 |
| CL | Benitez, A.Benitez, Armando † | Vikings | R | 75.0 | 48 | 0 | 1 | 0 | 4.53 | .308 | 1.29 | 7.8 | 4.0 | 7.4 | 45.2 | 39 | 23 | 23 | 8 | 20 | 37 | 0 | 26 | 0 | 0 | 0 | 2 | 0 | 5.13 |