| SP | Skubal, T.Skubal, Tarik † | Isotopes | L | 176.0 | 34 | 34 | 22 | 7 | 2.95 | .274 | 1.11 | 8.0 | 2.0 | 10.6 | 238.0 | 212 | 81 | 78 | 28 | 52 | 279 | 2 | 0 | 0 | 1 | 28 | 6 | 5 | 2.92 |
| SP | Rogers, T.Rogers, Trevor † | Dolphins | L | 137.0 | 34 | 34 | 18 | 8 | 3.44 | .276 | 1.13 | 7.1 | 3.0 | 7.8 | 238.0 | 189 | 96 | 91 | 31 | 79 | 205 | 3 | 0 | 0 | 2 | 21 | 4 | 0 | 4.02 |
| CL | Saalfrank, A.Saalfrank, Andrew † | Cubs | L | 123.0 | 97 | 0 | 6 | 3 | 3.52 | .295 | 1.20 | 6.8 | 4.1 | 6.8 | 120.1 | 90 | 52 | 47 | 11 | 55 | 90 | 0 | 30 | 2 | 0 | 0 | 6 | 5 | 4.22 |
| CL | Svanson, M.Svanson, Matt † | Homestead Grays | R | 120.5 | 67 | 0 | 5 | 8 | 2.39 | .281 | 1.13 | 6.1 | 4.2 | 10.9 | 71.2 | 48 | 22 | 19 | 10 | 33 | 86 | 0 | 35 | 3 | 0 | 0 | 3 | 0 | 3.93 |
| SP | Eovaldi, N.Eovaldi, Nathan | Lions | R | 114.0 | 35 | 35 | 14 | 9 | 3.15 | .288 | 1.17 | 7.6 | 2.9 | 7.0 | 231.2 | 196 | 93 | 81 | 20 | 74 | 180 | 0 | 0 | 0 | 0 | 26 | 11 | 8 | 3.67 |
| SP | Imanaga, S.Imanaga, Shota | Dolphins | L | 108.0 | 32 | 32 | 17 | 8 | 3.77 | .287 | 1.20 | 8.6 | 2.2 | 7.7 | 195.2 | 187 | 85 | 82 | 21 | 47 | 167 | 0 | 0 | 0 | 0 | 18 | 2 | 2 | 3.44 |