| SP | Arrieta, J.Arrieta, Jake † $$ | Sharks | R | 137.0 | 22 | 22 | 14 | 1 | 1.97 | .248 | 0.97 | 6.3 | 2.4 | 8.7 | 155.0 | 108 | 34 | 34 | 16 | 42 | 150 | 3 | 0 | 0 | 2 | 17 | 3 | 1 | 3.28 |
| SP | Kluber, C.Kluber, Corey † | Warriors | R | 115.0 | 21 | 21 | 13 | 8 | 2.99 | .238 | 0.91 | 6.7 | 1.5 | 10.1 | 165.1 | 123 | 55 | 55 | 22 | 28 | 186 | 11 | 0 | 0 | 4 | 14 | 4 | 6 | 3.06 |
| SP | deGrom, J.deGrom, Jacob † $$ | Warriors | R | 110.0 | 22 | 22 | 13 | 3 | 2.90 | .241 | 0.92 | 6.4 | 1.9 | 9.9 | 155.0 | 111 | 52 | 50 | 20 | 32 | 171 | 1 | 0 | 0 | 0 | 14 | 5 | 0 | 3.19 |
| SP | Santana, J.Santana, Johan # | Sharks | L | 95.0 | 22 | 22 | 12 | 5 | 3.13 | .256 | 1.03 | 7.0 | 2.3 | 10.2 | 144.0 | 112 | 50 | 50 | 19 | 37 | 163 | 2 | 0 | 0 | 0 | 15 | 0 | 2 | 3.22 |
| CL | Gagne, E.Gagne, Eric † $$ | Sharks | R | 89.5 | 48 | 0 | 2 | 4 | 2.40 | .249 | 0.96 | 5.3 | 3.4 | 11.4 | 56.1 | 33 | 15 | 15 | 4 | 21 | 71 | 0 | 27 | 1 | 0 | 0 | 2 | 1 | 2.63 |
| SP | Gooden, D.Gooden, Dwight † | Tigercats | R | 86.0 | 21 | 21 | 13 | 4 | 3.46 | .318 | 1.36 | 7.8 | 4.5 | 7.3 | 127.1 | 110 | 51 | 49 | 11 | 63 | 103 | 0 | 0 | 0 | 0 | 5 | 5 | 2 | 4.11 |
| SP | Scherzer, M.Scherzer, Max | TCU | R | 79.0 | 22 | 22 | 12 | 5 | 3.94 | .310 | 1.32 | 7.6 | 4.3 | 9.4 | 146.1 | 124 | 65 | 64 | 24 | 69 | 152 | 0 | 0 | 0 | 0 | 12 | 4 | 4 | 4.55 |
| SP | Strasburg, S.Strasburg, Stephen | TCU | R | 79.0 | 22 | 21 | 11 | 5 | 3.56 | .272 | 1.10 | 7.1 | 2.9 | 8.2 | 141.2 | 111 | 56 | 56 | 18 | 45 | 128 | 1 | 0 | 0 | 1 | 14 | 3 | 2 | 3.87 |