| SP | Hernandez, F.Hernandez, Felix † # | Mariners 3 | R | 171.0 | 27 | 27 | 21 | 4 | 2.91 | .245 | 0.96 | 6.8 | 1.9 | 9.0 | 198.0 | 149 | 67 | 64 | 17 | 42 | 199 | 10 | 0 | 0 | 2 | 19 | 2 | 5 | 2.77 |
| SP | deGrom, J.deGrom, Jacob † | Scum | R | 150.0 | 28 | 28 | 17 | 3 | 2.79 | .275 | 1.11 | 7.1 | 2.9 | 9.3 | 206.1 | 162 | 64 | 64 | 15 | 67 | 214 | 3 | 0 | 0 | 1 | 21 | 6 | 4 | 2.93 |
| SP | McLain, D.McLain, Denny # | Tigers | R | 123.0 | 27 | 27 | 14 | 8 | 3.40 | .263 | 1.05 | 7.3 | 2.2 | 6.2 | 220.0 | 179 | 85 | 83 | 29 | 53 | 151 | 13 | 0 | 0 | 5 | 17 | 3 | 1 | 4.10 |
| SP | Arrieta, J.Arrieta, Jake † | Cubbies | R | 120.0 | 28 | 28 | 15 | 7 | 3.40 | .284 | 1.18 | 8.1 | 2.5 | 9.1 | 209.1 | 187 | 83 | 79 | 19 | 59 | 212 | 3 | 0 | 0 | 2 | 16 | 3 | 1 | 3.04 |
| RP | Soriano, R.Soriano, Rafael † | Mariners 3 | R | 92.0 | 77 | 0 | 10 | 2 | 2.81 | .260 | 1.03 | 6.2 | 3.0 | 8.9 | 121.2 | 84 | 39 | 38 | 7 | 41 | 120 | 0 | 4 | 3 | 0 | 0 | 3 | 0 | 2.86 |
| SP | Skubal, T.Skubal, Tarik † | Tigers | L | 91.0 | 28 | 28 | 13 | 7 | 3.96 | .293 | 1.23 | 8.2 | 2.8 | 9.4 | 191.0 | 174 | 88 | 84 | 26 | 60 | 200 | 1 | 0 | 0 | 1 | 17 | 4 | 5 | 3.68 |
| RP | Sanchez, A.Sanchez, Aaron † | B12ue Jays | R | 90.0 | 80 | 0 | 10 | 5 | 2.27 | .264 | 1.07 | 6.8 | 2.9 | 7.2 | 126.2 | 95 | 39 | 32 | 12 | 41 | 101 | 0 | 2 | 1 | 0 | 0 | 0 | 4 | 3.61 |