| SP | deGrom, J.deGrom, Jacob † | Sharks | R | 133.0 | 20 | 20 | 14 | 0 | 1.79 | .245 | 0.94 | 6.4 | 2.1 | 10.5 | 140.2 | 99 | 29 | 28 | 11 | 33 | 163 | 1 | 0 | 0 | 0 | 19 | 5 | 0 | 2.51 |
| SP | Hunter, C.Hunter, Catfish † # | Red Bears | R | 127.0 | 19 | 19 | 14 | 4 | 2.41 | .248 | 0.99 | 7.1 | 1.8 | 6.4 | 160.1 | 126 | 46 | 43 | 19 | 32 | 114 | 9 | 0 | 0 | 2 | 13 | 1 | 0 | 3.74 |
| SP | Fernandez, J.Fernandez, Jose | Demons | R | 81.0 | 20 | 20 | 10 | 4 | 3.01 | .272 | 1.11 | 6.2 | 3.9 | 9.4 | 128.2 | 88 | 44 | 43 | 12 | 55 | 133 | 0 | 0 | 0 | 0 | 14 | 1 | 1 | 3.45 |
| SP | Kershaw, C.Kershaw, Clayton † | Gladiators | L | 79.0 | 20 | 20 | 8 | 8 | 3.33 | .253 | 1.01 | 7.5 | 1.6 | 9.6 | 159.2 | 133 | 71 | 59 | 20 | 28 | 170 | 9 | 0 | 0 | 3 | 11 | 1 | 5 | 3.04 |
| CL | Feliz, N.Feliz, Neftali † | Crawdads | R | 79.0 | 43 | 0 | 1 | 7 | 3.73 | .266 | 1.07 | 6.5 | 3.2 | 10.4 | 50.2 | 36 | 22 | 21 | 11 | 18 | 58 | 0 | 32 | 2 | 0 | 0 | 1 | 0 | 4.68 |
| CL | Kimbrel, C.Kimbrel, Craig † | Demon Dogs | R | 76.0 | 33 | 0 | 4 | 4 | 2.06 | .250 | 1.00 | 5.1 | 3.9 | 11.1 | 35.0 | 20 | 8 | 8 | 3 | 15 | 43 | 0 | 20 | 0 | 0 | 0 | 0 | 1 | 2.94 |