| SP | Scott, M.Scott, Mike † # + | Astros | R | 113.0 | 21 | 21 | 14 | 4 | 3.04 | .246 | 0.96 | 6.6 | 2.0 | 8.1 | 148.0 | 109 | 55 | 50 | 14 | 33 | 133 | 8 | 0 | 0 | 0 | 15 | 3 | 1 | 3.16 |
| SP | Martinez, P.Martinez, Pedro † + | Red Sox | R | 106.0 | 21 | 21 | 12 | 7 | 2.76 | .251 | 0.99 | 5.5 | 3.4 | 9.4 | 153.0 | 94 | 50 | 47 | 12 | 57 | 160 | 6 | 0 | 0 | 3 | 15 | 3 | 4 | 3.10 |
| CL | Holland, G.Holland, Greg † | Indians | R | 104.5 | 54 | 0 | 3 | 6 | 2.40 | .225 | 0.82 | 5.0 | 2.4 | 8.8 | 56.1 | 31 | 15 | 15 | 5 | 15 | 55 | 0 | 35 | 6 | 0 | 0 | 3 | 2 | 3.16 |
| SP | Snell, B.Snell, Blake † $ | Blue Jays | L | 101.0 | 21 | 21 | 12 | 4 | 2.59 | .241 | 0.94 | 5.5 | 3.0 | 7.4 | 142.2 | 87 | 45 | 41 | 8 | 47 | 117 | 2 | 0 | 0 | 1 | 15 | 2 | 4 | 3.12 |
| SP | Newhouser, H.Newhouser, Hal | Twins | L | 101.0 | 21 | 21 | 11 | 1 | 2.56 | .248 | 0.95 | 6.0 | 2.6 | 7.0 | 133.2 | 89 | 40 | 38 | 10 | 38 | 103 | 3 | 0 | 0 | 2 | 13 | 5 | 3 | 3.40 |
| SP | McDowell, S.McDowell, Sam + | Indians | L | 99.0 | 21 | 21 | 12 | 6 | 3.19 | .259 | 1.02 | 6.4 | 2.7 | 8.8 | 155.1 | 111 | 57 | 55 | 15 | 47 | 151 | 6 | 0 | 0 | 2 | 15 | 5 | 3 | 3.32 |
| SP | Kluber, C.Kluber, Corey # + | Indians | R | 93.0 | 21 | 21 | 11 | 6 | 2.93 | .251 | 0.97 | 6.1 | 2.7 | 9.5 | 150.1 | 101 | 53 | 49 | 14 | 45 | 159 | 2 | 0 | 0 | 1 | 15 | 5 | 3 | 3.09 |