| SP | Horlen, J.Horlen, Joe # + $$ | White Sox | R | 170.0 | 33 | 33 | 21 | 7 | 2.94 | .249 | 0.96 | 6.4 | 2.2 | 4.8 | 260.1 | 185 | 90 | 85 | 18 | 64 | 138 | 7 | 0 | 0 | 2 | 23 | 10 | 8 | 3.69 |
| SP | McDowell, S.McDowell, Sam † + | Indians | L | 163.0 | 32 | 32 | 18 | 8 | 2.64 | .267 | 1.06 | 5.8 | 3.8 | 8.1 | 241.2 | 155 | 76 | 71 | 15 | 102 | 216 | 6 | 0 | 0 | 3 | 23 | 7 | 3 | 3.37 |
| CL | Britton, Z.Britton, Zach † + | Orioles | L | 160.5 | 63 | 0 | 9 | 4 | 1.47 | .198 | 0.73 | 4.2 | 2.4 | 8.2 | 79.2 | 37 | 14 | 13 | 4 | 21 | 72 | 0 | 37 | 5 | 0 | 0 | 1 | 3 | 2.67 |
| SP | Kluber, C.Kluber, Corey # + | Indians | R | 150.0 | 33 | 33 | 18 | 11 | 3.13 | .249 | 0.97 | 6.8 | 2.0 | 8.6 | 247.2 | 186 | 90 | 86 | 22 | 54 | 235 | 8 | 0 | 0 | 4 | 22 | 7 | 3 | 3.00 |
| RP | Nathan, J.Nathan, Joe † + | Twins | R | 143.5 | 79 | 0 | 12 | 4 | 1.79 | .206 | 0.78 | 4.8 | 2.2 | 9.6 | 125.2 | 67 | 26 | 25 | 6 | 31 | 133 | 0 | 15 | 1 | 0 | 0 | 0 | 0 | 2.24 |
| RP | Eckersley, D.Eckersley, Dennis † + | Athletics | R | 137.5 | 83 | 0 | 8 | 2 | 2.21 | .248 | 0.97 | 6.9 | 1.8 | 8.0 | 151.0 | 116 | 46 | 37 | 11 | 30 | 134 | 0 | 19 | 3 | 0 | 0 | 3 | 3 | 2.83 |
| SP | Martinez, P.Martinez, Pedro † + | Red Sox | R | 135.0 | 33 | 33 | 16 | 9 | 3.16 | .267 | 1.07 | 6.9 | 2.7 | 9.0 | 227.2 | 175 | 87 | 80 | 12 | 69 | 226 | 7 | 0 | 0 | 2 | 18 | 5 | 4 | 2.67 |
| SP | Bauer, T.Bauer, Trevor # $ | Angels | R | 130.0 | 33 | 33 | 15 | 8 | 2.98 | .251 | 1.00 | 6.7 | 2.4 | 8.2 | 235.2 | 174 | 81 | 78 | 19 | 62 | 214 | 1 | 0 | 0 | 1 | 25 | 1 | 8 | 3.03 |