| SP | Keuchel, D.Keuchel, Dallas † | Quakers | L | 169.0 | 36 | 36 | 21 | 8 | 3.13 | .282 | 1.16 | 7.8 | 2.7 | 8.3 | 261.1 | 226 | 96 | 91 | 29 | 77 | 242 | 5 | 0 | 0 | 1 | 27 | 5 | 6 | 3.53 |
| SP | Greinke, Z.Greinke, Zack † # | Vikings | R | 162.0 | 35 | 35 | 18 | 9 | 3.09 | .265 | 1.06 | 7.7 | 1.8 | 8.2 | 265.0 | 227 | 92 | 91 | 26 | 54 | 242 | 9 | 0 | 0 | 5 | 23 | 5 | 5 | 3.12 |
| SP | Kershaw, C.Kershaw, Clayton † | Corn Pickers | L | 151.0 | 35 | 35 | 17 | 8 | 3.38 | .286 | 1.17 | 8.0 | 2.5 | 9.9 | 263.1 | 235 | 102 | 99 | 27 | 73 | 290 | 8 | 0 | 0 | 3 | 23 | 8 | 5 | 3.05 |
| CL | Chapman, A.Chapman, Aroldis † | Tide | L | 135.0 | 85 | 0 | 7 | 7 | 4.19 | .325 | 1.42 | 8.9 | 4.0 | 11.2 | 81.2 | 80 | 41 | 38 | 10 | 36 | 101 | 0 | 42 | 6 | 0 | 0 | 2 | 3 | 3.52 |
| SP | Scherzer, M.Scherzer, Max | Tide | R | 123.0 | 37 | 37 | 19 | 12 | 3.87 | .290 | 1.21 | 8.8 | 2.0 | 10.2 | 242.0 | 237 | 110 | 104 | 28 | 55 | 275 | 0 | 0 | 0 | 0 | 22 | 4 | 10 | 2.96 |
| CL | Betances, D.Betances, Dellin † | Quakers | R | 121.5 | 74 | 0 | 3 | 10 | 2.74 | .293 | 1.22 | 6.0 | 5.0 | 10.3 | 75.2 | 50 | 24 | 23 | 0 | 42 | 86 | 0 | 41 | 1 | 0 | 0 | 2 | 6 | 2.47 |
| SP | Iwakuma, H.Iwakuma, Hisashi # | Tide | R | 111.0 | 35 | 35 | 17 | 13 | 3.87 | .292 | 1.21 | 8.7 | 2.2 | 7.7 | 237.1 | 229 | 109 | 102 | 33 | 57 | 202 | 5 | 0 | 0 | 2 | 18 | 7 | 3 | 3.92 |