| SP | Keuchel, D.Keuchel, Dallas † | Quakers | L | 169.0 | 36 | 36 | 21 | 8 | 3.13 | .282 | 1.16 | 7.8 | 2.7 | 8.3 | 261.1 | 226 | 96 | 91 | 29 | 77 | 242 | 5 | 0 | 0 | 1 | 27 | 5 | 6 | 3.53 |
| SP | Greinke, Z.Greinke, Zack † # | Vikings | R | 162.0 | 35 | 35 | 18 | 9 | 3.09 | .265 | 1.06 | 7.7 | 1.8 | 8.2 | 265.0 | 227 | 92 | 91 | 26 | 54 | 242 | 9 | 0 | 0 | 5 | 23 | 5 | 5 | 3.12 |
| SP | Kershaw, C.Kershaw, Clayton † | Corn Pickers | L | 150.0 | 36 | 36 | 17 | 9 | 3.40 | .288 | 1.18 | 8.2 | 2.5 | 9.9 | 270.0 | 245 | 105 | 102 | 28 | 74 | 296 | 8 | 0 | 0 | 3 | 24 | 8 | 5 | 3.07 |
| CL | Chapman, A.Chapman, Aroldis † | Tide | L | 130.0 | 87 | 0 | 7 | 8 | 4.43 | .332 | 1.46 | 9.1 | 4.1 | 11.1 | 83.1 | 84 | 44 | 41 | 10 | 38 | 102 | 0 | 42 | 7 | 0 | 0 | 2 | 5 | 3.55 |
| SP | Scherzer, M.Scherzer, Max | Tide | R | 123.0 | 37 | 37 | 19 | 12 | 3.87 | .290 | 1.21 | 8.8 | 2.0 | 10.2 | 242.0 | 237 | 110 | 104 | 28 | 55 | 275 | 0 | 0 | 0 | 0 | 22 | 4 | 10 | 2.96 |
| CL | Betances, D.Betances, Dellin † | Quakers | R | 121.5 | 74 | 0 | 3 | 10 | 2.74 | .293 | 1.22 | 6.0 | 5.0 | 10.3 | 75.2 | 50 | 24 | 23 | 0 | 42 | 86 | 0 | 41 | 1 | 0 | 0 | 2 | 6 | 2.47 |
| SP | Iwakuma, H.Iwakuma, Hisashi # | Tide | R | 112.0 | 36 | 36 | 17 | 13 | 3.93 | .296 | 1.22 | 8.8 | 2.2 | 7.7 | 243.0 | 237 | 113 | 106 | 34 | 59 | 208 | 5 | 0 | 0 | 2 | 18 | 10 | 3 | 3.96 |