| SP | Maddux, G.Maddux, Greg † # | Warriors | R | 168.0 | 34 | 34 | 20 | 7 | 3.22 | .262 | 1.05 | 7.8 | 1.7 | 6.3 | 254.1 | 221 | 92 | 91 | 25 | 47 | 179 | 11 | 0 | 0 | 7 | 24 | 3 | 4 | 3.46 |
| SP | Martinez, P.Martinez, Pedro † # $ | Isotopes | R | 168.0 | 38 | 38 | 20 | 12 | 3.28 | .260 | 1.03 | 7.0 | 2.3 | 9.6 | 285.1 | 222 | 105 | 104 | 38 | 73 | 305 | 9 | 0 | 0 | 4 | 23 | 5 | 2 | 3.41 |
| CL | Doolittle, S.Doolittle, Sean † | Cyclones | L | 146.5 | 86 | 0 | 6 | 4 | 2.84 | .266 | 1.07 | 7.1 | 2.4 | 10.4 | 92.0 | 73 | 35 | 29 | 13 | 25 | 106 | 0 | 39 | 3 | 0 | 0 | 2 | 3 | 3.41 |
| CL | Street, H.Street, Huston † $ | Snake | R | 141.5 | 71 | 0 | 8 | 6 | 2.72 | .242 | 0.92 | 5.8 | 2.5 | 9.7 | 79.1 | 51 | 24 | 24 | 7 | 22 | 85 | 0 | 37 | 5 | 0 | 0 | 3 | 0 | 2.95 |
| SP | deGrom, J.deGrom, Jacob $ | Snake | R | 127.0 | 39 | 39 | 14 | 11 | 3.14 | .280 | 1.14 | 7.9 | 2.4 | 10.8 | 257.2 | 226 | 99 | 90 | 30 | 68 | 309 | 1 | 0 | 0 | 1 | 26 | 7 | 0 | 2.99 |
| SP | Verlander, J.Verlander, Justin † | Dogs | R | 118.0 | 34 | 34 | 14 | 8 | 3.48 | .292 | 1.22 | 8.0 | 3.0 | 9.9 | 232.2 | 207 | 93 | 90 | 25 | 78 | 255 | 4 | 0 | 0 | 1 | 20 | 3 | 5 | 3.25 |
| CL | Eckersley, D.Eckersley, Dennis $$ | Isotopes | R | 115.5 | 55 | 0 | 1 | 2 | 3.38 | .296 | 1.22 | 9.0 | 2.2 | 9.9 | 50.2 | 50 | 19 | 19 | 5 | 12 | 55 | 0 | 43 | 5 | 0 | 0 | 2 | 0 | 2.94 |
| SP | Greinke, Z.Greinke, Zack # $$ | Drinkers | R | 115.0 | 36 | 36 | 14 | 15 | 3.27 | .266 | 1.07 | 7.5 | 2.1 | 7.1 | 259.0 | 215 | 101 | 94 | 33 | 61 | 203 | 7 | 0 | 0 | 3 | 23 | 6 | 5 | 3.86 |