| SP | Eovaldi, N.Eovaldi, Nathan | Rays | R | 68.0 | 13 | 13 | 8 | 1 | 1.90 | .272 | 1.08 | 7.7 | 2.2 | 7.7 | 75.2 | 64 | 17 | 16 | 2 | 18 | 64 | 0 | 0 | 0 | 0 | 6 | 3 | 2 | 2.48 |
| CL | Castillo, D.Castillo, Diego | Rays | R | 60.0 | 27 | 0 | 1 | 1 | 2.63 | .255 | 1.02 | 7.0 | 2.3 | 11.3 | 27.1 | 21 | 9 | 8 | 2 | 7 | 34 | 0 | 20 | 2 | 0 | 0 | 0 | 0 | 2.22 |
| SP | Kluber, C.Kluber, Corey # | Indians | R | 56.0 | 13 | 13 | 7 | 1 | 3.67 | .284 | 1.13 | 7.9 | 2.3 | 11.3 | 90.2 | 79 | 37 | 37 | 12 | 23 | 113 | 1 | 0 | 0 | 0 | 9 | 6 | 2 | 3.19 |
| CL | Kimbrel, C.Kimbrel, Craig | Red Sox | R | 55.5 | 27 | 0 | 1 | 0 | 0.68 | .269 | 1.10 | 8.0 | 2.1 | 11.8 | 26.1 | 23 | 2 | 2 | 0 | 6 | 34 | 0 | 15 | 1 | 0 | 0 | 0 | 1 | 1.08 |
| SP | Montgomery, J.Montgomery, Jordan | Yankees | L | 52.0 | 13 | 13 | 7 | 3 | 3.07 | .274 | 1.10 | 7.5 | 2.4 | 8.2 | 82.0 | 68 | 28 | 28 | 9 | 22 | 75 | 0 | 0 | 0 | 0 | 9 | 3 | 2 | 3.51 |
| RP | Devenski, C.Devenski, Chris | Astros | R | 46.0 | 35 | 0 | 5 | 3 | 3.00 | .274 | 1.11 | 6.8 | 3.2 | 11.2 | 54.0 | 41 | 18 | 18 | 3 | 19 | 67 | 0 | 6 | 5 | 0 | 0 | 1 | 1 | 2.35 |
| SP | Johnson, B.Johnson, Brian | Red Sox | L | 45.0 | 12 | 12 | 5 | 2 | 2.84 | .292 | 1.21 | 8.3 | 2.6 | 8.5 | 76.0 | 70 | 27 | 24 | 5 | 22 | 72 | 0 | 0 | 0 | 0 | 7 | 2 | 0 | 2.91 |