| CL | Gregerson, L.Gregerson, Luke † | Astros | R | 142.5 | 61 | 0 | 3 | 5 | 1.59 | .218 | 0.82 | 5.5 | 1.9 | 9.0 | 62.1 | 38 | 12 | 11 | 3 | 13 | 62 | 0 | 45 | 3 | 0 | 0 | 1 | 4 | 2.31 |
| SP | Arrieta, J.Arrieta, Jake † | Cubs | R | 126.0 | 31 | 31 | 14 | 7 | 2.79 | .260 | 1.03 | 6.5 | 2.8 | 7.6 | 206.1 | 149 | 68 | 64 | 13 | 64 | 173 | 3 | 0 | 0 | 3 | 22 | 4 | 6 | 3.13 |
| CL | Rodriguez, F.Rodriguez, Francisco † | Angels | R | 123.5 | 60 | 0 | 1 | 5 | 2.58 | .267 | 1.08 | 5.5 | 4.3 | 8.7 | 59.1 | 36 | 17 | 17 | 3 | 28 | 57 | 0 | 45 | 3 | 0 | 0 | 1 | 1 | 3.20 |
| SP | Brecheen, H.Brecheen, Harry | Cardinals | L | 119.0 | 29 | 29 | 16 | 8 | 3.59 | .265 | 1.05 | 7.2 | 2.2 | 5.5 | 215.1 | 173 | 89 | 86 | 21 | 53 | 131 | 8 | 0 | 0 | 4 | 18 | 7 | 3 | 3.89 |
| CL | Chapman, A.Chapman, Aroldis † | Cubs | L | 108.5 | 69 | 0 | 3 | 7 | 3.57 | .315 | 1.38 | 8.9 | 3.6 | 8.6 | 68.0 | 67 | 27 | 27 | 7 | 27 | 65 | 0 | 39 | 5 | 0 | 0 | 0 | 3 | 3.62 |
| CL | Robinson, H.Robinson, Humberto # | Braves | R | 107.0 | 57 | 0 | 6 | 11 | 3.71 | .282 | 1.18 | 7.3 | 3.3 | 6.4 | 70.1 | 57 | 29 | 29 | 8 | 26 | 50 | 0 | 36 | 4 | 0 | 0 | 0 | 0 | 4.17 |