| SP | Hernandez, F.Hernandez, Felix † # | Dragons | R | 100.0 | 18 | 18 | 14 | 4 | 3.35 | .279 | 1.13 | 7.4 | 2.8 | 6.7 | 137.0 | 113 | 53 | 51 | 18 | 42 | 102 | 3 | 0 | 0 | 2 | 11 | 4 | 5 | 4.23 |
| SP | Clemens, R.Clemens, Roger † | Metro | R | 95.0 | 19 | 19 | 11 | 3 | 2.30 | .282 | 1.14 | 7.7 | 2.6 | 6.6 | 125.1 | 107 | 48 | 32 | 13 | 36 | 92 | 1 | 0 | 0 | 1 | 12 | 5 | 2 | 3.86 |
| SP | Schmidt, J.Schmidt, Jason † # | Sacrilege | R | 80.0 | 18 | 18 | 10 | 4 | 3.34 | .265 | 1.04 | 7.1 | 2.3 | 8.7 | 129.1 | 102 | 49 | 48 | 16 | 33 | 125 | 3 | 0 | 0 | 2 | 11 | 5 | 6 | 3.56 |
| SP | Vazquez, J.Vazquez, Javier † # | Steer | R | 79.0 | 18 | 18 | 11 | 3 | 3.75 | .289 | 1.19 | 8.4 | 2.3 | 8.5 | 127.1 | 119 | 55 | 53 | 14 | 33 | 120 | 2 | 0 | 0 | 1 | 13 | 3 | 3 | 3.39 |
| SP | Lincecum, T.Lincecum, Tim | Vikings | R | 69.0 | 18 | 18 | 9 | 5 | 3.65 | .294 | 1.20 | 7.6 | 3.2 | 9.3 | 138.0 | 117 | 57 | 56 | 13 | 49 | 142 | 2 | 0 | 0 | 1 | 10 | 6 | 4 | 3.36 |
| SP | Bedard, E.Bedard, Erik † # | Tiger Pride | L | 69.0 | 17 | 17 | 9 | 5 | 3.20 | .275 | 1.11 | 7.1 | 3.0 | 9.6 | 112.1 | 88 | 41 | 40 | 14 | 37 | 119 | 2 | 0 | 0 | 1 | 12 | 3 | 1 | 3.57 |
| CL | Papelbon, J.Papelbon, Jonathan † | Sacrilege | R | 61.5 | 42 | 0 | 2 | 3 | 3.38 | .310 | 1.32 | 9.0 | 3.0 | 8.2 | 45.1 | 45 | 17 | 17 | 4 | 15 | 41 | 0 | 21 | 6 | 0 | 0 | 1 | 1 | 3.40 |
| SP | Duchscherer, J.Duchscherer, Justin | GhastlyMonsters | R | 61.0 | 18 | 18 | 9 | 4 | 3.59 | .282 | 1.14 | 7.6 | 2.7 | 5.9 | 115.1 | 97 | 46 | 46 | 13 | 35 | 75 | 1 | 0 | 0 | 0 | 12 | 4 | 0 | 4.18 |