| RP | Messersmith, A.Messersmith, Andy † $$ | Other I's | R | 161.0 | 75 | 0 | 16 | 5 | 2.13 | .276 | 1.13 | 5.1 | 5.1 | 5.6 | 156.0 | 88 | 38 | 37 | 8 | 88 | 97 | 0 | 16 | 6 | 0 | 0 | 2 | 6 | 4.15 |
| SP | McDowell, S.McDowell, Sam † $ | Other I's | L | 151.0 | 34 | 34 | 17 | 9 | 3.05 | .286 | 1.20 | 6.4 | 4.5 | 8.0 | 262.1 | 185 | 95 | 89 | 7 | 130 | 232 | 7 | 0 | 0 | 2 | 22 | 1 | 16 | 3.08 |
| SP | Koufax, S.Koufax, Sandy † $ | Corporation | L | 136.0 | 33 | 33 | 14 | 12 | 2.47 | .263 | 1.06 | 7.0 | 2.5 | 7.1 | 244.1 | 190 | 79 | 67 | 16 | 69 | 193 | 4 | 0 | 0 | 2 | 26 | 3 | 1 | 3.16 |
| SP | Newhouser, H.Newhouser, Hal | Other I's | L | 127.0 | 33 | 33 | 17 | 10 | 3.73 | .293 | 1.22 | 7.6 | 3.4 | 4.7 | 256.0 | 215 | 109 | 106 | 19 | 97 | 133 | 11 | 0 | 0 | 4 | 17 | 6 | 8 | 4.13 |
| SP | Bonham, T.Bonham, Tiny # $$ | BlueClaws | R | 122.0 | 32 | 32 | 18 | 10 | 3.54 | .291 | 1.22 | 8.3 | 2.7 | 3.3 | 228.2 | 211 | 94 | 90 | 20 | 69 | 83 | 9 | 0 | 0 | 1 | 20 | 2 | 0 | 4.35 |
| CL | Wilhelm, H.Wilhelm, Hoyt $$ | Corporation | R | 116.5 | 64 | 0 | 9 | 12 | 3.12 | .303 | 1.28 | 7.4 | 4.2 | 5.1 | 83.2 | 68 | 32 | 29 | 5 | 39 | 47 | 0 | 33 | 7 | 0 | 0 | 2 | 2 | 4.13 |
| CL | Staley, J.Staley, Jerry † | BlueClaws | R | 114.0 | 60 | 0 | 4 | 6 | 2.95 | .271 | 1.10 | 6.9 | 3.0 | 4.0 | 61.0 | 47 | 20 | 20 | 5 | 20 | 27 | 0 | 38 | 4 | 0 | 0 | 1 | 0 | 4.21 |