| SP | Alexander, P.Alexander, Pete † | Suns | R | 172.0 | 33 | 33 | 21 | 10 | 2.93 | .279 | 1.15 | 7.7 | 2.7 | 4.8 | 261.1 | 222 | 92 | 85 | 16 | 78 | 139 | 13 | 0 | 0 | 3 | 22 | 4 | 5 | 3.67 |
| SP | deGrom, J.deGrom, Jacob † | Attack Eagles | R | 154.0 | 35 | 35 | 19 | 10 | 2.89 | .259 | 1.03 | 7.4 | 2.0 | 9.0 | 240.0 | 196 | 94 | 77 | 25 | 52 | 240 | 2 | 0 | 0 | 1 | 25 | 4 | 0 | 3.05 |
| SP | Arrieta, J.Arrieta, Jake † | Attack Eagles | R | 153.0 | 32 | 32 | 19 | 7 | 3.07 | .272 | 1.11 | 7.3 | 2.7 | 7.0 | 243.1 | 197 | 87 | 83 | 15 | 72 | 190 | 5 | 0 | 0 | 0 | 23 | 4 | 2 | 3.18 |
| CL | Doolittle, S.Doolittle, Sean † | Pirates | L | 145.0 | 67 | 0 | 8 | 5 | 2.27 | .252 | 0.98 | 6.6 | 2.3 | 9.9 | 71.1 | 52 | 20 | 18 | 6 | 18 | 78 | 0 | 36 | 2 | 0 | 0 | 2 | 0 | 2.75 |
| SP | Pfiester, J.Pfiester, Jack # | Lions | L | 124.0 | 33 | 33 | 17 | 12 | 3.85 | .296 | 1.25 | 8.1 | 3.1 | 4.9 | 252.1 | 228 | 125 | 108 | 18 | 88 | 137 | 15 | 0 | 0 | 5 | 17 | 2 | 4 | 3.91 |
| CL | Kimbrel, C.Kimbrel, Craig † | Fighting Pigs | R | 121.5 | 62 | 0 | 7 | 6 | 2.71 | .261 | 1.05 | 6.3 | 3.3 | 10.8 | 69.2 | 48 | 27 | 21 | 3 | 25 | 83 | 0 | 33 | 7 | 0 | 0 | 1 | 4 | 2.29 |