| SP | Koufax, S.Koufax, Sandy † | Headache | L | 87.0 | 17 | 17 | 11 | 5 | 2.99 | .265 | 1.07 | 6.8 | 2.9 | 8.3 | 129.1 | 97 | 49 | 43 | 17 | 42 | 119 | 5 | 0 | 0 | 0 | 12 | 1 | 1 | 3.87 |
| SP | Leonard, D.Leonard, Dutch † | Sharks | L | 73.0 | 16 | 16 | 9 | 1 | 2.86 | .275 | 1.12 | 6.4 | 3.7 | 5.6 | 107.0 | 76 | 38 | 34 | 5 | 44 | 67 | 0 | 0 | 0 | 0 | 13 | 2 | 0 | 3.64 |
| SP | Alexander, P.Alexander, Pete † # | Headache | R | 69.0 | 16 | 16 | 9 | 3 | 3.17 | .241 | 0.94 | 7.2 | 1.2 | 4.4 | 116.1 | 93 | 42 | 41 | 10 | 16 | 57 | 2 | 0 | 0 | 1 | 10 | 2 | 2 | 3.60 |
| SP | Mathewson, C.Mathewson, Christy | Sharks | R | 65.0 | 16 | 16 | 10 | 4 | 3.53 | .279 | 1.13 | 7.8 | 2.5 | 5.2 | 109.2 | 94 | 47 | 43 | 13 | 30 | 63 | 1 | 0 | 0 | 0 | 11 | 3 | 1 | 4.30 |
| CL | Doolittle, S.Doolittle, Sean † | Headache | L | 62.5 | 31 | 0 | 1 | 4 | 2.30 | .248 | 0.99 | 6.7 | 2.3 | 9.0 | 27.1 | 20 | 8 | 7 | 1 | 7 | 27 | 0 | 23 | 2 | 0 | 0 | 0 | 0 | 2.26 |