| SP | Johnson, R.Johnson, Randy | Mariners | L | 140.0 | 25 | 25 | 17 | 7 | 2.89 | .283 | 1.17 | 6.6 | 3.9 | 10.0 | 193.1 | 142 | 64 | 62 | 18 | 84 | 214 | 6 | 0 | 0 | 1 | 19 | 3 | 1 | 3.35 |
| RP | Benoit, J.Benoit, Joaquin † | Devil Rays | R | 126.0 | 85 | 0 | 17 | 4 | 3.04 | .294 | 1.22 | 8.0 | 3.1 | 9.4 | 112.1 | 99 | 41 | 38 | 6 | 38 | 117 | 0 | 8 | 4 | 0 | 0 | 3 | 2 | 2.71 |
| SP | Clemens, R.Clemens, Roger † | Blue Jays | R | 120.0 | 25 | 25 | 16 | 7 | 3.18 | .307 | 1.30 | 7.8 | 4.0 | 8.7 | 175.2 | 151 | 64 | 62 | 9 | 78 | 170 | 3 | 0 | 0 | 2 | 16 | 5 | 4 | 3.15 |
| SP | Santana, J.Santana, Johan | Twins | L | 115.0 | 26 | 26 | 12 | 6 | 2.67 | .248 | 0.96 | 6.4 | 2.3 | 8.8 | 185.2 | 131 | 67 | 55 | 23 | 47 | 180 | 3 | 0 | 0 | 2 | 18 | 6 | 0 | 3.53 |
| SP | McDowell, S.McDowell, Sam | Guardians | L | 109.0 | 25 | 25 | 14 | 6 | 3.16 | .300 | 1.26 | 7.1 | 4.2 | 8.6 | 176.2 | 139 | 65 | 62 | 12 | 83 | 168 | 2 | 0 | 0 | 0 | 17 | 5 | 4 | 3.48 |