| SP | Leonard, D.Leonard, Dutch † | Red Hose | L | 194.0 | 34 | 34 | 24 | 6 | 2.38 | .264 | 1.07 | 6.8 | 2.8 | 6.5 | 238.0 | 179 | 69 | 63 | 12 | 75 | 171 | 3 | 0 | 0 | 0 | 27 | 2 | 2 | 3.19 |
| SP | Richard, J.Richard, J.R. † | Astros | R | 176.0 | 35 | 35 | 21 | 7 | 2.35 | .259 | 1.04 | 6.2 | 3.1 | 7.4 | 222.0 | 154 | 59 | 58 | 16 | 77 | 183 | 3 | 0 | 0 | 2 | 23 | 2 | 3 | 3.36 |
| SP | Kershaw, C.Kershaw, Clayton | Dodgers | L | 149.0 | 35 | 35 | 18 | 6 | 3.35 | .277 | 1.14 | 8.6 | 1.6 | 8.9 | 252.1 | 241 | 97 | 94 | 39 | 46 | 248 | 4 | 0 | 0 | 1 | 24 | 3 | 4 | 3.63 |
| SP | Verlander, J.Verlander, Justin | Astros | R | 144.0 | 57 | 0 | 21 | 4 | 2.96 | .261 | 1.05 | 7.5 | 2.0 | 10.4 | 149.0 | 124 | 49 | 49 | 13 | 33 | 172 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.51 |
| CL | Jansen, K.Jansen, Kenley † | Dodgers | R | 140.0 | 82 | 0 | 4 | 6 | 2.77 | .269 | 1.09 | 5.9 | 4.0 | 9.6 | 81.1 | 53 | 29 | 25 | 8 | 36 | 86 | 0 | 44 | 5 | 0 | 0 | 1 | 4 | 3.53 |
| SP | Steele, E.Steele, Elmer † | Red Hose | R | 139.0 | 32 | 32 | 18 | 9 | 3.54 | .286 | 1.20 | 8.5 | 2.2 | 5.1 | 254.1 | 241 | 106 | 100 | 26 | 63 | 144 | 10 | 0 | 0 | 4 | 20 | 2 | 0 | 3.96 |
| CL | Pressly, R.Pressly, Ryan † | Astros | R | 136.0 | 67 | 0 | 4 | 6 | 3.27 | .298 | 1.24 | 7.2 | 4.0 | 9.3 | 66.0 | 53 | 24 | 24 | 8 | 29 | 68 | 0 | 46 | 4 | 0 | 0 | 2 | 0 | 3.92 |
| SP | Martinez, P.Martinez, Pedro † | Nat12nals | R | 124.0 | 37 | 37 | 17 | 13 | 3.87 | .285 | 1.19 | 7.5 | 3.2 | 9.1 | 260.1 | 216 | 116 | 112 | 29 | 93 | 263 | 11 | 0 | 0 | 1 | 19 | 3 | 0 | 3.53 |
| SP | Scherzer, M.Scherzer, Max | Nat12nals | R | 113.0 | 35 | 35 | 16 | 10 | 3.53 | .286 | 1.20 | 7.2 | 3.6 | 8.8 | 214.1 | 171 | 87 | 84 | 19 | 86 | 210 | 1 | 0 | 0 | 1 | 21 | 1 | 0 | 3.41 |