| SP | Buchholz, C.Buchholz, Clay † | Crabs | R | 128.0 | 27 | 27 | 16 | 6 | 2.98 | .285 | 1.18 | 6.9 | 3.7 | 7.4 | 196.1 | 151 | 69 | 65 | 20 | 80 | 161 | 3 | 0 | 0 | 1 | 20 | 4 | 4 | 3.97 |
| SP | Scherzer, M.Scherzer, Max | Rauna | R | 121.0 | 29 | 29 | 15 | 7 | 3.22 | .283 | 1.14 | 7.0 | 3.3 | 10.3 | 201.1 | 157 | 73 | 72 | 19 | 73 | 231 | 1 | 0 | 0 | 1 | 21 | 8 | 1 | 3.14 |
| CL | Doolittle, S.Doolittle, Sean † | Mets | L | 103.0 | 73 | 0 | 3 | 8 | 3.46 | .267 | 1.05 | 6.8 | 2.8 | 10.9 | 80.2 | 60 | 33 | 31 | 7 | 25 | 97 | 0 | 34 | 2 | 0 | 0 | 3 | 1 | 2.76 |
| SP | Verlander, J.Verlander, Justin | Sharks | R | 97.0 | 29 | 29 | 12 | 8 | 3.44 | .260 | 1.03 | 7.3 | 1.9 | 11.0 | 183.1 | 149 | 74 | 70 | 23 | 39 | 223 | 4 | 0 | 0 | 0 | 19 | 5 | 2 | 2.92 |
| SP | Arrieta, J.Arrieta, Jake # | Pigs | R | 96.0 | 29 | 29 | 14 | 9 | 4.05 | .295 | 1.21 | 8.6 | 2.4 | 9.6 | 191.1 | 182 | 86 | 86 | 18 | 50 | 204 | 5 | 0 | 0 | 2 | 17 | 8 | 8 | 3.00 |
| CL | Chapman, A.Chapman, Aroldis † | Hell Raisers | L | 91.0 | 70 | 0 | 4 | 6 | 3.67 | .298 | 1.22 | 5.9 | 5.1 | 10.2 | 81.0 | 53 | 33 | 33 | 8 | 46 | 92 | 0 | 26 | 1 | 0 | 0 | 4 | 4 | 3.86 |