| CL | Svanson, M.Svanson, Matt † | Eruptions | R | 118.5 | 44 | 0 | 5 | 1 | 1.89 | .247 | 0.90 | 4.8 | 3.4 | 9.4 | 47.2 | 25 | 10 | 10 | 4 | 18 | 49 | 0 | 31 | 2 | 0 | 0 | 4 | 2 | 3.43 |
| SP | Rogers, T.Rogers, Trevor † | Spiders | L | 112.0 | 20 | 20 | 13 | 2 | 2.44 | .245 | 0.96 | 6.5 | 2.2 | 8.8 | 136.2 | 98 | 38 | 37 | 5 | 33 | 133 | 1 | 0 | 0 | 1 | 18 | 2 | 0 | 2.29 |
| CL | Chapman, A.Chapman, Aroldis † | Bees | L | 76.0 | 45 | 0 | 2 | 1 | 1.29 | .270 | 1.11 | 6.4 | 3.8 | 13.1 | 48.2 | 34 | 7 | 7 | 2 | 20 | 70 | 0 | 18 | 1 | 0 | 0 | 0 | 6 | 1.88 |
| SP | Glasnow, T.Glasnow, Tyler † | Eruptions | R | 73.0 | 19 | 19 | 9 | 2 | 2.74 | .289 | 1.17 | 6.9 | 3.7 | 8.4 | 101.2 | 77 | 31 | 31 | 6 | 42 | 94 | 0 | 0 | 0 | 0 | 5 | 5 | 3 | 3.31 |
| SP | deGrom, J.deGrom, Jacob # | Pigs | R | 69.0 | 20 | 20 | 8 | 8 | 2.63 | .260 | 1.03 | 7.0 | 2.3 | 9.3 | 130.0 | 101 | 40 | 38 | 15 | 33 | 135 | 0 | 0 | 0 | 0 | 14 | 3 | 1 | 3.25 |
| SP | Skubal, T.Skubal, Tarik † | Elephants | L | 66.0 | 20 | 20 | 8 | 10 | 3.07 | .271 | 1.09 | 7.8 | 2.1 | 11.2 | 140.2 | 121 | 54 | 48 | 11 | 32 | 174 | 2 | 0 | 0 | 1 | 15 | 4 | 1 | 2.31 |