| SP | Shields, J.Shields, James | Rays | R | 96.0 | 27 | 27 | 12 | 5 | 3.36 | .283 | 1.16 | 8.7 | 1.7 | 6.9 | 182.0 | 176 | 75 | 68 | 17 | 35 | 139 | 2 | 0 | 0 | 0 | 20 | 5 | 3 | 3.35 |
| SP | Santana, J.Santana, Johan # | Twins | L | 93.0 | 27 | 27 | 15 | 9 | 4.34 | .278 | 1.12 | 8.8 | 1.3 | 9.3 | 193.0 | 189 | 93 | 93 | 28 | 28 | 200 | 6 | 0 | 0 | 0 | 16 | 6 | 3 | 3.34 |
| SP | Verlander, J.Verlander, Justin | Tigers | R | 85.0 | 27 | 27 | 12 | 8 | 3.77 | .300 | 1.25 | 8.3 | 3.0 | 7.6 | 188.2 | 174 | 83 | 79 | 19 | 62 | 158 | 3 | 0 | 0 | 0 | 19 | 7 | 7 | 3.73 |
| SP | Hernandez, F.Hernandez, Felix # | Mariners | R | 79.0 | 27 | 27 | 11 | 12 | 4.11 | .282 | 1.15 | 8.4 | 2.0 | 9.0 | 195.0 | 181 | 93 | 89 | 25 | 43 | 196 | 11 | 0 | 0 | 2 | 15 | 6 | 8 | 3.41 |
| SP | Galarraga, A.Galarraga, Armando | Tigers | R | 75.0 | 27 | 27 | 13 | 9 | 4.18 | .312 | 1.32 | 7.8 | 4.1 | 7.1 | 168.0 | 145 | 82 | 78 | 20 | 76 | 132 | 1 | 0 | 0 | 1 | 17 | 8 | 1 | 4.48 |
| CL | Balfour, G.Balfour, Grant | Rays | R | 72.5 | 57 | 0 | 1 | 6 | 4.88 | .343 | 1.55 | 9.5 | 4.6 | 10.4 | 51.2 | 54 | 29 | 28 | 4 | 26 | 59 | 0 | 33 | 7 | 0 | 0 | 1 | 1 | 3.29 |
| SP | Liriano, F.Liriano, Francisco | Twins | L | 72.0 | 27 | 27 | 8 | 5 | 2.76 | .282 | 1.18 | 7.9 | 2.7 | 9.6 | 127.0 | 112 | 44 | 39 | 13 | 38 | 135 | 0 | 0 | 0 | 0 | 4 | 0 | 7 | 3.10 |
| CL | Turnbow, D.Turnbow, Derrick | Brewers | R | 72.0 | 45 | 0 | 4 | 7 | 3.68 | .294 | 1.25 | 8.2 | 3.1 | 9.8 | 44.0 | 40 | 20 | 18 | 7 | 15 | 48 | 0 | 24 | 4 | 0 | 0 | 0 | 4 | 3.91 |