| SP | Halladay, R.Halladay, Roy † | Phillies | R | 148.0 | 33 | 32 | 18 | 9 | 3.06 | .278 | 1.13 | 8.2 | 2.0 | 7.5 | 244.0 | 221 | 90 | 83 | 19 | 55 | 203 | 7 | 0 | 0 | 1 | 22 | 6 | 2 | 3.10 |
| RP | Holland, G.Holland, Greg † | Nationals | R | 144.0 | 72 | 0 | 8 | 7 | 3.42 | .275 | 1.10 | 6.5 | 3.5 | 10.0 | 73.2 | 53 | 30 | 28 | 5 | 28 | 81 | 0 | 42 | 5 | 0 | 0 | 3 | 1 | 2.95 |
| SP | Hendricks, K.Hendricks, Kyle † | Cubs | R | 128.0 | 35 | 35 | 18 | 7 | 3.45 | .300 | 1.26 | 8.2 | 3.2 | 7.5 | 219.0 | 199 | 90 | 84 | 19 | 78 | 183 | 0 | 0 | 0 | 0 | 23 | 4 | 3 | 3.58 |
| CL | Chapman, A.Chapman, Aroldis † | Cubs | L | 127.5 | 72 | 0 | 0 | 5 | 3.05 | .256 | 1.02 | 5.1 | 4.0 | 11.4 | 65.0 | 37 | 24 | 22 | 7 | 29 | 82 | 0 | 49 | 5 | 0 | 0 | 1 | 5 | 3.26 |
| RP | Frieri, E.Frieri, Ernesto † | Padres | R | 124.0 | 67 | 0 | 11 | 2 | 2.04 | .285 | 1.18 | 6.4 | 4.3 | 10.5 | 83.2 | 59 | 21 | 19 | 6 | 40 | 97 | 0 | 16 | 2 | 0 | 0 | 1 | 2 | 3.08 |
| SP | Eickhoff, J.Eickhoff, Jerad † | Phillies | R | 123.0 | 33 | 33 | 18 | 9 | 3.92 | .300 | 1.24 | 8.0 | 3.2 | 10.5 | 227.1 | 203 | 105 | 99 | 29 | 80 | 266 | 1 | 0 | 0 | 1 | 20 | 9 | 1 | 3.49 |
| RP | Boxberger, B.Boxberger, Brad † | Phillies | R | 113.5 | 58 | 0 | 6 | 4 | 2.48 | .293 | 1.19 | 6.7 | 4.0 | 12.3 | 58.0 | 43 | 17 | 16 | 4 | 26 | 79 | 0 | 29 | 3 | 0 | 0 | 3 | 1 | 2.67 |