| SP | Arrieta, J.Arrieta, Jake † # | Cubbies | R | 189.0 | 39 | 39 | 19 | 12 | 2.73 | .256 | 1.01 | 6.6 | 2.5 | 8.4 | 310.0 | 226 | 96 | 94 | 18 | 86 | 288 | 11 | 0 | 0 | 5 | 27 | 8 | 5 | 2.81 |
| SP | Reulbach, E.Reulbach, Ed † | Cubbies | R | 157.0 | 38 | 38 | 21 | 10 | 3.12 | .294 | 1.24 | 7.0 | 4.1 | 5.3 | 274.0 | 213 | 104 | 95 | 16 | 126 | 162 | 2 | 0 | 0 | 0 | 28 | 3 | 3 | 3.99 |
| SP | Manoah, A.Manoah, Alek † # | Blue Jays | R | 154.0 | 35 | 35 | 20 | 7 | 3.16 | .281 | 1.13 | 7.7 | 2.5 | 6.1 | 250.1 | 214 | 90 | 88 | 20 | 70 | 169 | 2 | 0 | 0 | 2 | 24 | 9 | 2 | 3.64 |
| CL | Greene, S.Greene, Shane † | Gritty Tigs 2 | R | 152.5 | 63 | 0 | 6 | 4 | 2.00 | .262 | 1.06 | 5.1 | 4.4 | 6.6 | 63.0 | 36 | 14 | 14 | 6 | 31 | 46 | 0 | 43 | 1 | 0 | 0 | 0 | 0 | 4.25 |
| SP | Eovaldi, N.Eovaldi, Nathan # | Rangers | R | 141.0 | 38 | 38 | 21 | 8 | 3.75 | .264 | 1.06 | 7.8 | 1.7 | 8.0 | 240.0 | 209 | 100 | 100 | 25 | 45 | 212 | 1 | 0 | 0 | 1 | 24 | 4 | 14 | 3.20 |
| SP | Greinke, Z.Greinke, Zack † | Cactus Kings | R | 141.0 | 33 | 33 | 17 | 8 | 2.90 | .266 | 1.06 | 7.1 | 2.5 | 6.8 | 235.2 | 185 | 76 | 76 | 24 | 65 | 178 | 3 | 0 | 0 | 1 | 25 | 6 | 4 | 3.72 |
| SP | Sabathia, C.Sabathia, CC # | Brewers | L | 134.0 | 33 | 33 | 20 | 8 | 4.01 | .300 | 1.28 | 9.1 | 2.5 | 7.5 | 235.2 | 238 | 110 | 105 | 21 | 64 | 197 | 8 | 0 | 0 | 1 | 19 | 1 | 3 | 3.31 |
| CL | Hudson, B.Hudson, Bryan † | Brewers | L | 128.0 | 60 | 0 | 5 | 6 | 2.37 | .252 | 1.00 | 6.0 | 3.0 | 7.7 | 68.1 | 45 | 22 | 18 | 1 | 23 | 58 | 0 | 38 | 3 | 0 | 0 | 1 | 2 | 2.54 |