| SP | McDowell, S.McDowell, Sam | Indians | L | 143.0 | 32 | 31 | 18 | 9 | 3.18 | .285 | 1.17 | 7.1 | 3.5 | 7.7 | 223.2 | 176 | 87 | 79 | 12 | 86 | 192 | 9 | 0 | 0 | 2 | 20 | 5 | 8 | 3.20 |
| SP | Darvish, Y.Darvish, Yu † # | Rangers | R | 142.0 | 31 | 31 | 19 | 3 | 3.48 | .299 | 1.26 | 7.6 | 3.7 | 8.3 | 207.0 | 174 | 82 | 80 | 23 | 86 | 192 | 2 | 0 | 0 | 0 | 20 | 5 | 3 | 3.91 |
| SP | deGrom, J.deGrom, Jacob † | Rangers | R | 127.0 | 31 | 31 | 19 | 5 | 3.68 | .284 | 1.16 | 8.1 | 2.5 | 8.5 | 190.2 | 170 | 82 | 78 | 23 | 52 | 180 | 0 | 0 | 0 | 0 | 17 | 5 | 2 | 3.58 |
| SP | Koufax, S.Koufax, Sandy † | Brooklyners | L | 126.0 | 33 | 33 | 17 | 16 | 3.47 | .277 | 1.15 | 7.7 | 2.6 | 6.6 | 254.0 | 218 | 107 | 98 | 24 | 73 | 187 | 13 | 0 | 0 | 2 | 21 | 1 | 6 | 3.63 |
| SP | Caldwell, R.Caldwell, Ray † | Yanks | R | 124.0 | 31 | 31 | 18 | 9 | 3.40 | .290 | 1.19 | 7.7 | 3.0 | 4.3 | 220.0 | 188 | 89 | 83 | 20 | 74 | 106 | 4 | 0 | 0 | 1 | 21 | 8 | 10 | 4.34 |
| SP | Maddux, G.Maddux, Greg † # | Ballaz | R | 118.0 | 34 | 31 | 16 | 12 | 3.71 | .287 | 1.20 | 8.9 | 1.9 | 5.6 | 254.2 | 251 | 113 | 105 | 28 | 54 | 157 | 10 | 0 | 0 | 3 | 18 | 2 | 5 | 3.86 |