| SP | Skubal, T.Skubal, Tarik † | Pirates | L | 115.0 | 28 | 28 | 13 | 5 | 2.93 | .262 | 1.03 | 6.7 | 2.6 | 11.1 | 181.1 | 134 | 60 | 59 | 21 | 53 | 224 | 1 | 0 | 0 | 0 | 21 | 6 | 2 | 3.01 |
| CL | Chapman, A.Chapman, Aroldis † | Bees | L | 114.0 | 85 | 0 | 5 | 3 | 2.53 | .300 | 1.24 | 6.8 | 4.5 | 11.4 | 92.2 | 69 | 27 | 26 | 8 | 46 | 117 | 0 | 26 | 4 | 0 | 0 | 4 | 8 | 3.22 |
| CL | Svanson, M.Svanson, Matt † | Scooters | R | 111.0 | 63 | 0 | 6 | 6 | 4.61 | .310 | 1.32 | 7.0 | 4.9 | 11.1 | 68.1 | 53 | 36 | 35 | 11 | 37 | 84 | 0 | 36 | 6 | 0 | 0 | 2 | 0 | 4.35 |
| CL | Miller, M.Miller, Mason † | Pirates | R | 110.5 | 57 | 0 | 2 | 5 | 3.17 | .314 | 1.33 | 6.8 | 5.2 | 12.3 | 54.0 | 41 | 19 | 19 | 3 | 31 | 74 | 0 | 39 | 4 | 0 | 0 | 2 | 0 | 2.81 |
| SP | Yamamoto, Y.Yamamoto, Yoshinobu † | Scooters | R | 109.0 | 28 | 28 | 13 | 7 | 2.89 | .282 | 1.15 | 6.5 | 3.9 | 9.9 | 174.1 | 125 | 58 | 56 | 11 | 75 | 192 | 1 | 0 | 0 | 1 | 17 | 5 | 7 | 2.99 |
| SP | Schwellenbach, S.Schwellenbach, Spencer † | Pirates | R | 94.0 | 27 | 27 | 14 | 8 | 3.78 | .284 | 1.16 | 8.2 | 2.3 | 8.2 | 188.0 | 171 | 84 | 79 | 25 | 48 | 171 | 1 | 0 | 0 | 0 | 17 | 5 | 4 | 3.76 |
| SP | Sanchez, C.Sanchez, Cristopher | Scooters | L | 91.0 | 27 | 27 | 13 | 7 | 3.79 | .299 | 1.23 | 8.2 | 2.9 | 9.9 | 171.0 | 155 | 73 | 72 | 22 | 55 | 188 | 2 | 0 | 0 | 0 | 17 | 9 | 2 | 3.60 |
| CL | Cleavinger, G.Cleavinger, Garrett | Bombers | L | 91.0 | 72 | 0 | 3 | 7 | 3.19 | .284 | 1.16 | 6.7 | 3.8 | 10.8 | 79.0 | 59 | 30 | 28 | 8 | 33 | 95 | 0 | 28 | 2 | 0 | 0 | 2 | 0 | 3.24 |