| SP | Brown, M.Brown, Mordecai † | Frogs | R | 131.0 | 24 | 24 | 15 | 4 | 2.86 | .257 | 1.02 | 6.9 | 2.3 | 3.9 | 195.0 | 149 | 64 | 62 | 12 | 49 | 85 | 8 | 0 | 0 | 3 | 17 | 4 | 2 | 3.74 |
| SP | Reulbach, E.Reulbach, Ed † | Floss Farmers | R | 119.0 | 24 | 24 | 14 | 5 | 2.61 | .256 | 1.01 | 4.9 | 4.2 | 3.9 | 179.1 | 98 | 52 | 52 | 12 | 83 | 77 | 5 | 0 | 0 | 1 | 20 | 4 | 4 | 4.47 |
| SP | Arrieta, J.Arrieta, Jake # | Hitmen | R | 109.0 | 25 | 25 | 13 | 6 | 3.34 | .264 | 1.03 | 6.8 | 2.5 | 8.5 | 183.0 | 138 | 69 | 68 | 20 | 51 | 173 | 7 | 0 | 0 | 2 | 16 | 8 | 3 | 3.50 |
| SP | Fernandez, S.Fernandez, Sid | Floss Farmers | L | 101.0 | 25 | 25 | 14 | 7 | 3.21 | .287 | 1.20 | 6.5 | 4.3 | 7.7 | 168.0 | 122 | 63 | 60 | 13 | 80 | 143 | 1 | 0 | 0 | 0 | 18 | 1 | 2 | 3.75 |
| SP | Kershaw, C.Kershaw, Clayton | Ducks | L | 99.0 | 25 | 25 | 12 | 9 | 3.29 | .276 | 1.10 | 8.2 | 1.8 | 8.2 | 194.1 | 176 | 74 | 71 | 18 | 38 | 176 | 6 | 0 | 0 | 1 | 17 | 8 | 7 | 3.10 |
| SP | Verlander, J.Verlander, Justin † # | Hitmen | R | 98.0 | 26 | 26 | 15 | 9 | 3.73 | .271 | 1.09 | 7.3 | 2.6 | 7.8 | 181.0 | 146 | 79 | 75 | 26 | 52 | 156 | 3 | 0 | 0 | 0 | 16 | 4 | 2 | 4.07 |
| CL | Kimbrel, C.Kimbrel, Craig † | Dodgers | R | 92.5 | 50 | 0 | 2 | 3 | 3.15 | .272 | 1.09 | 5.8 | 4.0 | 11.0 | 54.1 | 35 | 19 | 19 | 6 | 24 | 66 | 0 | 31 | 5 | 0 | 0 | 2 | 3 | 3.44 |