| SP | Santana, J.Santana, Johan † # | Gators | L | 132.0 | 35 | 35 | 17 | 9 | 3.55 | .275 | 1.12 | 7.0 | 3.1 | 9.5 | 253.1 | 196 | 105 | 100 | 26 | 87 | 268 | 3 | 0 | 0 | 0 | 19 | 5 | 6 | 3.31 |
| SP | Greinke, Z.Greinke, Zack † | Brown | R | 104.0 | 32 | 32 | 17 | 4 | 4.42 | .325 | 1.42 | 9.0 | 3.8 | 9.2 | 179.0 | 179 | 94 | 88 | 20 | 76 | 182 | 1 | 0 | 0 | 0 | 15 | 3 | 5 | 3.74 |
| SP | Johnson, R.Johnson, Randy # | Bears | L | 103.0 | 37 | 37 | 14 | 12 | 4.10 | .304 | 1.27 | 8.7 | 2.8 | 10.8 | 254.2 | 246 | 116 | 116 | 33 | 78 | 305 | 4 | 0 | 0 | 3 | 19 | 10 | 7 | 3.33 |
| SP | Jimenez, U.Jimenez, Ubaldo † # | Plunder | R | 99.0 | 31 | 31 | 14 | 9 | 3.90 | .294 | 1.22 | 7.7 | 3.3 | 7.1 | 224.0 | 192 | 100 | 97 | 26 | 82 | 177 | 4 | 0 | 0 | 2 | 16 | 6 | 6 | 4.11 |
| SP | Pettitte, A.Pettitte, Andy | Eagles | L | 95.0 | 33 | 33 | 16 | 9 | 4.17 | .288 | 1.20 | 8.5 | 2.3 | 6.9 | 207.1 | 196 | 100 | 96 | 28 | 52 | 159 | 1 | 0 | 0 | 0 | 15 | 4 | 2 | 4.03 |