| SP | deGrom, J.deGrom, Jacob † $ | Brawlers | R | 138.0 | 34 | 34 | 19 | 11 | 3.46 | .282 | 1.14 | 7.5 | 2.7 | 9.6 | 242.0 | 202 | 98 | 93 | 26 | 73 | 258 | 3 | 0 | 0 | 0 | 21 | 10 | 2 | 3.29 |
| SP | Kershaw, C.Kershaw, Clayton † # | Lions | L | 136.0 | 36 | 36 | 18 | 13 | 3.69 | .287 | 1.19 | 8.8 | 1.9 | 9.5 | 273.1 | 267 | 116 | 112 | 34 | 57 | 288 | 8 | 0 | 0 | 1 | 22 | 6 | 6 | 3.20 |
| SP | Cueto, J.Cueto, Johnny † # | Plunder | R | 133.0 | 35 | 35 | 17 | 10 | 3.61 | .284 | 1.15 | 7.7 | 2.6 | 8.3 | 249.0 | 213 | 103 | 100 | 27 | 73 | 231 | 7 | 0 | 0 | 4 | 21 | 10 | 4 | 3.55 |
| SP | Buchholz, C.Buchholz, Clay | Brawlers | R | 130.0 | 33 | 33 | 17 | 8 | 3.17 | .303 | 1.29 | 7.8 | 3.8 | 7.6 | 213.0 | 185 | 80 | 75 | 24 | 89 | 179 | 2 | 0 | 0 | 2 | 21 | 4 | 1 | 4.09 |
| SP | Scherzer, M.Scherzer, Max † | Tigers | R | 129.0 | 36 | 36 | 17 | 11 | 3.53 | .301 | 1.25 | 7.6 | 3.7 | 11.0 | 229.2 | 194 | 92 | 90 | 20 | 93 | 280 | 3 | 0 | 0 | 3 | 25 | 9 | 6 | 3.03 |
| SP | Fernandez, J.Fernandez, Jose | Brown | R | 127.0 | 34 | 33 | 17 | 6 | 3.38 | .277 | 1.13 | 6.7 | 3.5 | 9.1 | 205.0 | 153 | 77 | 77 | 22 | 79 | 207 | 1 | 0 | 0 | 0 | 21 | 4 | 5 | 3.59 |
| RP | Benoit, J.Benoit, Joaquin † | Tigers | R | 109.5 | 91 | 0 | 9 | 1 | 2.92 | .261 | 1.04 | 7.2 | 2.3 | 10.6 | 132.1 | 105 | 43 | 43 | 9 | 33 | 156 | 0 | 11 | 4 | 0 | 0 | 2 | 2 | 2.32 |