| SP | Scherzer, M.Scherzer, Max | Tigers | R | 111.0 | 22 | 22 | 14 | 3 | 3.01 | .279 | 1.12 | 7.1 | 3.0 | 7.9 | 155.1 | 122 | 57 | 52 | 14 | 52 | 136 | 2 | 0 | 0 | 0 | 16 | 6 | 1 | 3.54 |
| SP | Skubal, T.Skubal, Tarik † | Tigers | L | 106.0 | 23 | 23 | 15 | 7 | 3.23 | .296 | 1.24 | 8.8 | 2.3 | 9.4 | 161.2 | 158 | 60 | 58 | 7 | 42 | 169 | 0 | 0 | 0 | 0 | 18 | 4 | 0 | 2.32 |
| RP | Bieber, S.Bieber, Shane † | Indians | R | 101.0 | 46 | 0 | 14 | 5 | 2.64 | .273 | 1.09 | 6.4 | 3.4 | 8.9 | 109.0 | 78 | 32 | 32 | 4 | 41 | 108 | 0 | 2 | 1 | 0 | 0 | 4 | 8 | 2.73 |
| SP | Schilling, C.Schilling, Curt † # | Phillies | R | 101.0 | 21 | 20 | 14 | 1 | 2.99 | .266 | 1.07 | 6.9 | 2.7 | 4.9 | 126.1 | 97 | 43 | 42 | 9 | 38 | 69 | 0 | 0 | 0 | 0 | 13 | 2 | 2 | 3.79 |
| SP | Siebert, S.Siebert, Sonny † | Indians | R | 100.0 | 22 | 22 | 14 | 5 | 3.31 | .319 | 1.37 | 7.6 | 4.8 | 6.0 | 149.2 | 126 | 63 | 55 | 15 | 79 | 100 | 4 | 0 | 0 | 1 | 13 | 5 | 1 | 4.66 |
| SP | Strider, S.Strider, Spencer | Braves | R | 93.0 | 22 | 22 | 12 | 1 | 3.19 | .280 | 1.15 | 6.7 | 3.7 | 8.9 | 127.0 | 94 | 45 | 45 | 8 | 52 | 126 | 0 | 0 | 0 | 0 | 8 | 2 | 5 | 3.11 |