| SP | Flaherty, J.Flaherty, Jack † | Tigers | R | 125.0 | 21 | 21 | 17 | 2 | 2.94 | .278 | 1.13 | 8.4 | 1.8 | 7.8 | 141.0 | 132 | 49 | 46 | 15 | 28 | 122 | 1 | 0 | 0 | 1 | 16 | 3 | 2 | 3.31 |
| SP | Skubal, T.Skubal, Tarik † | Tigers | L | 111.0 | 22 | 22 | 12 | 4 | 2.35 | .252 | 0.99 | 6.4 | 2.5 | 9.2 | 153.0 | 108 | 42 | 40 | 5 | 43 | 156 | 1 | 0 | 0 | 0 | 19 | 4 | 2 | 2.31 |
| RP | Greene, S.Greene, Shane † | Tigers | R | 94.0 | 56 | 0 | 10 | 0 | 3.24 | .279 | 1.09 | 6.1 | 3.7 | 9.6 | 75.0 | 51 | 30 | 27 | 7 | 31 | 80 | 0 | 10 | 1 | 0 | 0 | 5 | 0 | 3.52 |
| SP | Tannehill, J.Tannehill, Jesse # | Pirates | L | 93.0 | 20 | 20 | 11 | 6 | 3.23 | .277 | 1.15 | 8.5 | 1.9 | 4.8 | 170.0 | 160 | 70 | 61 | 14 | 35 | 91 | 9 | 0 | 0 | 1 | 13 | 0 | 0 | 3.62 |
| SP | Buchholz, C.Buchholz, Clay | Colt 45's | R | 87.0 | 22 | 22 | 13 | 5 | 3.69 | .309 | 1.31 | 8.9 | 2.9 | 6.8 | 144.0 | 142 | 64 | 59 | 13 | 46 | 108 | 1 | 0 | 0 | 1 | 13 | 5 | 0 | 3.74 |
| RP | Doolittle, S.Doolittle, Sean † | Nation3ls | L | 85.5 | 60 | 0 | 13 | 2 | 2.58 | .245 | 0.98 | 6.0 | 2.9 | 9.0 | 69.2 | 46 | 21 | 20 | 3 | 22 | 69 | 0 | 1 | 1 | 0 | 0 | 0 | 5 | 2.52 |