| SP | Hernandez, F.Hernandez, Felix | Mariners | R | 42.0 | 10 | 10 | 6 | 3 | 3.30 | .306 | 1.30 | 8.1 | 3.5 | 6.8 | 71.0 | 64 | 27 | 26 | 5 | 28 | 54 | 1 | 0 | 0 | 0 | 7 | 2 | 2 | 3.66 |
| CL | Benoit, J.Benoit, Joaquin | Rangers | R | 40.5 | 22 | 0 | 1 | 0 | 3.18 | .284 | 1.19 | 8.6 | 2.5 | 8.6 | 22.2 | 21 | 8 | 8 | 5 | 6 | 21 | 0 | 13 | 2 | 0 | 0 | 0 | 0 | 4.86 |
| CL | Pestano, V.Pestano, Vinnie | Indians | R | 40.5 | 17 | 0 | 0 | 1 | 2.25 | .284 | 1.19 | 5.6 | 5.1 | 9.0 | 16.0 | 10 | 4 | 4 | 2 | 9 | 16 | 0 | 15 | 0 | 0 | 0 | 0 | 0 | 4.31 |
| SP | Santana, J.Santana, Johan | Twins | L | 40.0 | 9 | 9 | 6 | 3 | 3.78 | .273 | 1.13 | 8.5 | 1.8 | 8.2 | 66.2 | 62 | 28 | 28 | 6 | 13 | 60 | 2 | 0 | 0 | 1 | 5 | 0 | 2 | 2.95 |
| SP | Halladay, R.Halladay, Roy | Blue Jays | R | 40.0 | 9 | 9 | 5 | 2 | 2.85 | .309 | 1.34 | 10.0 | 2.2 | 6.0 | 66.1 | 73 | 23 | 21 | 5 | 16 | 44 | 1 | 0 | 0 | 0 | 8 | 0 | 0 | 3.38 |
| SP | Bonderman, J.Bonderman, Jeremy | Tigers | R | 40.0 | 9 | 9 | 4 | 3 | 2.87 | .281 | 1.17 | 8.3 | 2.2 | 8.0 | 69.0 | 64 | 23 | 22 | 7 | 17 | 61 | 3 | 0 | 0 | 2 | 6 | 0 | 1 | 3.29 |