| SP | Santana, J.Santana, Johan † # | Gunslingers | L | 153.0 | 39 | 39 | 20 | 8 | 3.41 | .259 | 1.03 | 6.8 | 2.5 | 8.4 | 253.1 | 191 | 98 | 96 | 35 | 71 | 237 | 4 | 0 | 0 | 2 | 26 | 4 | 3 | 3.81 |
| CL | Doolittle, S.Doolittle, Sean † | Pirates | L | 151.5 | 78 | 0 | 3 | 4 | 2.21 | .263 | 1.03 | 7.1 | 2.2 | 8.9 | 81.1 | 64 | 21 | 20 | 9 | 20 | 80 | 0 | 47 | 4 | 0 | 0 | 3 | 1 | 3.32 |
| CL | Benoit, J.Benoit, Joaquin † | Toro’s | R | 144.0 | 76 | 0 | 9 | 7 | 3.22 | .259 | 1.05 | 6.5 | 3.0 | 9.9 | 86.2 | 62 | 32 | 31 | 9 | 29 | 95 | 0 | 38 | 5 | 0 | 0 | 0 | 1 | 3.16 |
| SP | Kershaw, C.Kershaw, Clayton | Gunslingers | L | 143.0 | 40 | 40 | 15 | 11 | 3.17 | .273 | 1.09 | 8.1 | 1.7 | 9.4 | 278.0 | 249 | 107 | 98 | 34 | 54 | 291 | 7 | 0 | 0 | 3 | 27 | 10 | 10 | 3.19 |
| SP | Martinez, P.Martinez, Pedro | Aviators | R | 130.0 | 36 | 36 | 16 | 16 | 3.16 | .257 | 1.01 | 7.2 | 1.9 | 10.0 | 250.1 | 200 | 90 | 88 | 30 | 54 | 277 | 7 | 0 | 0 | 2 | 25 | 6 | 3 | 3.06 |
| SP | Gooden, D.Gooden, Dwight † # | Aviators | R | 126.0 | 34 | 34 | 15 | 10 | 3.35 | .272 | 1.09 | 7.4 | 2.4 | 7.0 | 244.1 | 201 | 95 | 91 | 25 | 65 | 190 | 8 | 0 | 0 | 4 | 19 | 8 | 3 | 3.67 |
| SP | Arrieta, J.Arrieta, Jake † | Pirates | R | 118.0 | 35 | 35 | 17 | 9 | 3.80 | .298 | 1.26 | 7.9 | 3.5 | 8.9 | 229.2 | 201 | 102 | 97 | 25 | 89 | 226 | 2 | 0 | 0 | 1 | 23 | 3 | 7 | 3.65 |