| CL | Doolittle, S.Doolittle, Sean † | Pirates | L | 151.0 | 76 | 0 | 3 | 3 | 2.04 | .261 | 1.02 | 6.9 | 2.3 | 8.8 | 79.1 | 61 | 19 | 18 | 9 | 20 | 77 | 0 | 46 | 4 | 0 | 0 | 3 | 1 | 3.41 |
| SP | Santana, J.Santana, Johan † # | Gunslingers | L | 143.0 | 33 | 33 | 18 | 6 | 3.22 | .249 | 0.98 | 6.5 | 2.4 | 8.2 | 220.2 | 158 | 81 | 79 | 29 | 58 | 201 | 4 | 0 | 0 | 2 | 22 | 3 | 3 | 3.72 |
| CL | Benoit, J.Benoit, Joaquin † | Toro’s | R | 137.0 | 73 | 0 | 9 | 7 | 3.38 | .264 | 1.08 | 6.7 | 3.1 | 9.9 | 82.2 | 61 | 32 | 31 | 9 | 28 | 90 | 0 | 36 | 5 | 0 | 0 | 0 | 1 | 3.26 |
| SP | Martinez, P.Martinez, Pedro | Aviators | R | 132.0 | 35 | 35 | 16 | 15 | 3.09 | .258 | 1.02 | 7.3 | 1.9 | 9.9 | 242.0 | 195 | 85 | 83 | 28 | 51 | 266 | 7 | 0 | 0 | 2 | 25 | 6 | 3 | 3.01 |
| SP | Arrieta, J.Arrieta, Jake † | Pirates | R | 121.0 | 34 | 34 | 17 | 9 | 3.66 | .296 | 1.25 | 7.8 | 3.5 | 9.0 | 224.0 | 193 | 96 | 91 | 25 | 86 | 223 | 2 | 0 | 0 | 1 | 23 | 3 | 6 | 3.65 |
| SP | Gooden, D.Gooden, Dwight † # | Aviators | R | 118.0 | 32 | 32 | 14 | 9 | 3.40 | .269 | 1.08 | 7.4 | 2.3 | 7.0 | 230.0 | 189 | 91 | 87 | 24 | 59 | 179 | 8 | 0 | 0 | 4 | 17 | 6 | 3 | 3.65 |
| SP | Kershaw, C.Kershaw, Clayton | Gunslingers | L | 109.0 | 35 | 35 | 12 | 10 | 3.46 | .279 | 1.13 | 8.5 | 1.6 | 9.6 | 237.0 | 225 | 97 | 91 | 31 | 43 | 252 | 6 | 0 | 0 | 2 | 22 | 7 | 9 | 3.21 |