| SP | Newcombe, D.Newcombe, Don † | Indians | R | 189.0 | 37 | 37 | 16 | 9 | 2.15 | .227 | 0.88 | 5.6 | 2.3 | 4.6 | 301.1 | 188 | 80 | 72 | 15 | 77 | 154 | 19 | 0 | 0 | 1 | 29 | 0 | 2 | 3.39 |
| SP | Paige, S.Paige, Satchel † | Browns | R | 163.0 | 37 | 37 | 19 | 14 | 3.11 | .271 | 1.11 | 7.0 | 3.0 | 6.8 | 295.1 | 231 | 106 | 102 | 22 | 98 | 222 | 14 | 0 | 0 | 3 | 28 | 1 | 0 | 3.47 |
| SP | Stratton, M.Stratton, Monty † | White Sox | R | 143.0 | 37 | 37 | 18 | 13 | 2.95 | .262 | 1.06 | 8.0 | 1.5 | 3.8 | 274.2 | 244 | 100 | 90 | 21 | 47 | 117 | 8 | 0 | 0 | 0 | 25 | 2 | 0 | 3.68 |
| SP | Reynolds, A.Reynolds, Allie | Indians | R | 124.0 | 36 | 36 | 17 | 7 | 3.13 | .286 | 1.20 | 6.8 | 4.1 | 4.2 | 216.0 | 162 | 81 | 75 | 13 | 98 | 101 | 0 | 0 | 0 | 0 | 21 | 0 | 2 | 4.21 |
| CL | Eisenstat, H.Eisenstat, Harry † | Indians | L | 122.5 | 50 | 0 | 7 | 7 | 1.77 | .262 | 1.07 | 7.7 | 1.9 | 3.7 | 71.1 | 61 | 18 | 14 | 2 | 15 | 29 | 0 | 31 | 3 | 0 | 0 | 0 | 2 | 3.18 |
| CL | Gabler, F.Gabler, Frank † | White Sox | R | 121.5 | 56 | 0 | 0 | 3 | 3.16 | .274 | 1.13 | 7.2 | 3.0 | 1.9 | 51.1 | 41 | 18 | 18 | 1 | 17 | 11 | 0 | 49 | 5 | 0 | 0 | 0 | 2 | 3.82 |