| SP | Schmidt, J.Schmidt, Jason † | Gunslingers | R | 197.0 | 36 | 36 | 22 | 10 | 2.70 | .265 | 1.06 | 6.3 | 3.2 | 8.9 | 280.1 | 197 | 88 | 84 | 28 | 99 | 278 | 11 | 0 | 0 | 2 | 28 | 7 | 5 | 3.45 |
| SP | Burnett, A.Burnett, A.J. † | Isotopes | R | 138.0 | 33 | 33 | 17 | 6 | 2.83 | .290 | 1.20 | 7.3 | 3.5 | 7.3 | 213.1 | 173 | 74 | 67 | 20 | 83 | 172 | 0 | 0 | 0 | 0 | 23 | 6 | 5 | 3.86 |
| SP | Zambrano, C.Zambrano, Carlos | Gunslingers | R | 138.0 | 36 | 36 | 15 | 10 | 3.03 | .286 | 1.18 | 7.5 | 3.1 | 6.6 | 270.0 | 226 | 93 | 91 | 25 | 92 | 199 | 6 | 0 | 0 | 2 | 25 | 6 | 4 | 3.82 |
| SP | Johnson, R.Johnson, Randy † | Isotopes | L | 137.0 | 33 | 33 | 16 | 11 | 3.18 | .280 | 1.14 | 7.8 | 2.5 | 9.3 | 249.0 | 216 | 90 | 88 | 27 | 68 | 257 | 7 | 0 | 0 | 1 | 22 | 7 | 3 | 3.25 |
| CL | Benitez, A.Benitez, Armando † | Flamethrowers | R | 123.5 | 74 | 0 | 4 | 4 | 2.88 | .240 | 0.92 | 5.2 | 3.2 | 7.4 | 68.2 | 39 | 24 | 22 | 9 | 24 | 56 | 0 | 39 | 5 | 0 | 0 | 2 | 0 | 4.22 |
| SP | Carpenter, C.Carpenter, Chris | 2000-2009 | R | 122.0 | 33 | 33 | 13 | 8 | 3.04 | .271 | 1.10 | 7.6 | 2.3 | 6.9 | 242.2 | 205 | 91 | 82 | 20 | 61 | 186 | 5 | 0 | 0 | 1 | 25 | 4 | 5 | 3.34 |
| SP | Arroyo, B.Arroyo, Bronson † # | GrenadeLauncher | R | 120.0 | 32 | 32 | 15 | 7 | 3.05 | .268 | 1.08 | 7.1 | 2.7 | 6.9 | 203.1 | 160 | 71 | 69 | 15 | 60 | 155 | 2 | 0 | 0 | 2 | 17 | 3 | 5 | 3.36 |
| CL | Gonzalez, M.Gonzalez, Mike | Isotopes | L | 118.5 | 88 | 0 | 6 | 13 | 4.15 | .281 | 1.16 | 8.1 | 2.4 | 9.7 | 95.1 | 86 | 47 | 44 | 16 | 25 | 102 | 0 | 43 | 9 | 0 | 0 | 1 | 5 | 3.86 |