| SP | Sanchez, S.Sanchez, Sixto † | Cubs | R | 146.0 | 27 | 27 | 19 | 1 | 3.27 | .257 | 1.02 | 7.1 | 2.0 | 7.0 | 189.2 | 150 | 76 | 69 | 22 | 43 | 148 | 3 | 0 | 0 | 2 | 19 | 4 | 2 | 3.69 |
| CL | Williams, D.Williams, Devin † + | Astros | R | 124.5 | 53 | 0 | 0 | 1 | 1.63 | .251 | 0.99 | 4.6 | 4.4 | 13.6 | 49.2 | 25 | 11 | 9 | 2 | 24 | 74 | 0 | 43 | 5 | 0 | 0 | 1 | 1 | 2.04 |
| SP | Fernandez, J.Fernandez, Jose † | Cubs | R | 121.0 | 27 | 27 | 14 | 8 | 3.36 | .274 | 1.11 | 7.8 | 2.3 | 9.7 | 203.2 | 175 | 81 | 76 | 32 | 51 | 219 | 13 | 0 | 0 | 0 | 18 | 5 | 2 | 3.72 |
| SP | Valdez, F.Valdez, Framber † # | Astros | L | 117.0 | 27 | 27 | 15 | 6 | 2.88 | .243 | 0.95 | 5.4 | 3.1 | 9.3 | 172.0 | 104 | 62 | 55 | 12 | 59 | 178 | 0 | 0 | 0 | 0 | 18 | 3 | 12 | 2.92 |
| SP | Flaherty, J.Flaherty, Jack | Cardinals | R | 109.0 | 27 | 27 | 13 | 7 | 3.38 | .278 | 1.14 | 7.4 | 2.9 | 10.1 | 189.1 | 155 | 71 | 71 | 22 | 61 | 213 | 6 | 0 | 0 | 1 | 18 | 3 | 2 | 3.28 |
| SP | Yamamoto, J.Yamamoto, Jordan | Rockies | R | 103.0 | 27 | 27 | 15 | 6 | 3.86 | .277 | 1.10 | 7.4 | 2.5 | 9.1 | 179.2 | 148 | 81 | 77 | 20 | 50 | 181 | 3 | 0 | 0 | 0 | 15 | 8 | 3 | 3.40 |
| SP | Bieber, S.Bieber, Shane † + | Astros | R | 96.0 | 27 | 27 | 11 | 8 | 3.33 | .269 | 1.06 | 6.9 | 2.7 | 11.2 | 186.1 | 142 | 72 | 69 | 23 | 55 | 231 | 2 | 0 | 0 | 2 | 17 | 9 | 5 | 3.16 |