| SP | Koufax, S.Koufax, Sandy † # $ | Warriors | L | 218.0 | 35 | 35 | 23 | 8 | 2.65 | .253 | 1.00 | 6.9 | 2.1 | 7.6 | 288.2 | 222 | 90 | 85 | 22 | 68 | 244 | 18 | 0 | 0 | 6 | 26 | 4 | 8 | 3.05 |
| SP | Tiant, L.Tiant, Luis † $$ | Phils | R | 169.0 | 34 | 34 | 18 | 9 | 2.85 | .294 | 1.23 | 7.2 | 4.0 | 7.0 | 265.2 | 211 | 88 | 84 | 12 | 117 | 205 | 14 | 0 | 0 | 3 | 23 | 4 | 5 | 3.41 |
| SP | Newhouser, H.Newhouser, Hal # | Phils | L | 163.0 | 34 | 34 | 20 | 6 | 3.02 | .277 | 1.14 | 7.2 | 3.1 | 6.3 | 241.2 | 194 | 88 | 81 | 14 | 82 | 170 | 7 | 0 | 0 | 2 | 25 | 2 | 7 | 3.39 |
| SP | McLain, D.McLain, Denny † | Dragons | R | 158.0 | 37 | 37 | 21 | 12 | 3.61 | .299 | 1.27 | 8.4 | 3.0 | 5.2 | 304.0 | 285 | 128 | 122 | 25 | 101 | 175 | 15 | 0 | 0 | 2 | 22 | 3 | 3 | 3.94 |
| CL | Messersmith, A.Messersmith, Andy † $$ | Phils | R | 144.5 | 64 | 0 | 9 | 9 | 2.96 | .291 | 1.23 | 6.8 | 4.3 | 6.0 | 112.2 | 85 | 37 | 37 | 6 | 54 | 75 | 0 | 37 | 6 | 0 | 0 | 0 | 1 | 3.80 |
| SP | Marichal, J.Marichal, Juan † $$ | Pilgrims | R | 122.0 | 35 | 35 | 18 | 14 | 3.94 | .286 | 1.20 | 8.6 | 2.2 | 4.0 | 267.1 | 256 | 120 | 117 | 31 | 64 | 120 | 17 | 0 | 0 | 2 | 17 | 1 | 4 | 4.34 |