| CL | McMahon, D.McMahon, Don † | Rainiers | R | 160.0 | 76 | 0 | 9 | 8 | 2.85 | .309 | 1.32 | 7.2 | 4.7 | 4.3 | 79.0 | 63 | 26 | 25 | 4 | 41 | 38 | 0 | 46 | 5 | 0 | 0 | 2 | 1 | 4.33 |
| SP | Koufax, S.Koufax, Sandy † | Phils | L | 149.0 | 37 | 37 | 19 | 16 | 3.53 | .292 | 1.23 | 7.9 | 3.2 | 6.9 | 283.1 | 249 | 121 | 111 | 20 | 100 | 217 | 19 | 0 | 0 | 3 | 23 | 1 | 9 | 3.46 |
| SP | Downing, A.Downing, Al † $ | Horses | L | 140.0 | 34 | 34 | 18 | 8 | 3.24 | .300 | 1.26 | 6.5 | 4.9 | 5.5 | 241.2 | 173 | 91 | 87 | 12 | 131 | 148 | 5 | 0 | 0 | 3 | 24 | 7 | 3 | 4.14 |
| SP | Drysdale, D.Drysdale, Don | Horses | R | 111.0 | 32 | 32 | 15 | 10 | 3.28 | .281 | 1.16 | 8.1 | 2.4 | 4.3 | 224.2 | 202 | 102 | 82 | 18 | 59 | 108 | 5 | 0 | 0 | 0 | 19 | 2 | 3 | 3.90 |
| RP | Messersmith, A.Messersmith, Andy † | Warriors | R | 106.5 | 79 | 0 | 8 | 8 | 3.28 | .297 | 1.25 | 6.9 | 4.4 | 4.7 | 137.1 | 105 | 53 | 50 | 9 | 67 | 71 | 0 | 21 | 1 | 0 | 0 | 2 | 7 | 4.33 |