| SP | Koufax, S.Koufax, Sandy † # $ | Warriors | L | 217.0 | 36 | 36 | 23 | 8 | 2.74 | .257 | 1.02 | 7.1 | 2.2 | 7.6 | 296.0 | 232 | 95 | 90 | 23 | 71 | 250 | 18 | 0 | 0 | 6 | 26 | 4 | 8 | 3.08 |
| SP | Tiant, L.Tiant, Luis † $$ | Phils | R | 163.0 | 35 | 35 | 18 | 10 | 3.02 | .296 | 1.25 | 7.3 | 4.0 | 6.9 | 271.1 | 219 | 95 | 91 | 13 | 120 | 207 | 14 | 0 | 0 | 3 | 23 | 4 | 5 | 3.47 |
| SP | McLain, D.McLain, Denny † | Dragons | R | 158.0 | 37 | 37 | 21 | 12 | 3.61 | .299 | 1.27 | 8.4 | 3.0 | 5.2 | 304.0 | 285 | 128 | 122 | 25 | 101 | 175 | 15 | 0 | 0 | 2 | 22 | 3 | 3 | 3.94 |
| SP | Newhouser, H.Newhouser, Hal # | Phils | L | 158.0 | 35 | 35 | 20 | 7 | 3.19 | .281 | 1.17 | 7.5 | 3.0 | 6.4 | 245.1 | 203 | 95 | 87 | 14 | 83 | 173 | 7 | 0 | 0 | 2 | 25 | 2 | 8 | 3.37 |
| CL | Messersmith, A.Messersmith, Andy † $$ | Phils | R | 144.5 | 64 | 0 | 9 | 9 | 2.96 | .291 | 1.23 | 6.8 | 4.3 | 6.0 | 112.2 | 85 | 37 | 37 | 6 | 54 | 75 | 0 | 37 | 6 | 0 | 0 | 0 | 1 | 3.80 |
| SP | Marichal, J.Marichal, Juan † $$ | Pilgrims | R | 122.0 | 35 | 35 | 18 | 14 | 3.94 | .286 | 1.20 | 8.6 | 2.2 | 4.0 | 267.1 | 256 | 120 | 117 | 31 | 64 | 120 | 17 | 0 | 0 | 2 | 17 | 1 | 4 | 4.34 |