| SP | Downing, A.Downing, Al † $$ | Horses | L | 136.0 | 21 | 21 | 15 | 4 | 2.29 | .261 | 1.04 | 5.6 | 3.8 | 4.7 | 168.2 | 105 | 45 | 43 | 5 | 71 | 88 | 8 | 0 | 0 | 4 | 17 | 3 | 1 | 3.66 |
| SP | Tiant, L.Tiant, Luis † # $ | Phils | R | 92.0 | 22 | 22 | 9 | 4 | 3.10 | .258 | 1.04 | 6.5 | 2.8 | 7.5 | 165.2 | 120 | 58 | 57 | 19 | 52 | 137 | 10 | 0 | 0 | 0 | 15 | 1 | 2 | 3.80 |
| CL | Messersmith, A.Messersmith, Andy † $ | Phils | R | 87.5 | 31 | 0 | 10 | 4 | 2.61 | .265 | 1.08 | 5.6 | 4.1 | 5.7 | 76.0 | 47 | 22 | 22 | 3 | 35 | 48 | 0 | 11 | 6 | 0 | 0 | 0 | 0 | 3.63 |
| SP | Newhouser, H.Newhouser, Hal | Warriors | L | 83.0 | 21 | 21 | 11 | 5 | 3.43 | .300 | 1.29 | 7.6 | 4.0 | 4.5 | 154.2 | 130 | 62 | 59 | 15 | 69 | 77 | 5 | 0 | 0 | 1 | 13 | 0 | 3 | 4.61 |
| SP | Koufax, S.Koufax, Sandy † | Serpents | L | 83.0 | 22 | 22 | 9 | 5 | 3.26 | .290 | 1.21 | 8.1 | 2.8 | 7.6 | 163.0 | 147 | 64 | 59 | 13 | 51 | 138 | 5 | 0 | 0 | 1 | 15 | 2 | 2 | 3.32 |
| CL | Abernathy, T.Abernathy, Ted † | Rainiers | R | 82.0 | 41 | 0 | 2 | 7 | 2.50 | .300 | 1.29 | 7.4 | 4.4 | 6.9 | 39.2 | 32 | 14 | 11 | 3 | 19 | 30 | 0 | 30 | 1 | 0 | 0 | 0 | 0 | 3.92 |
| SP | Drysdale, D.Drysdale, Don # | Horses | R | 81.0 | 21 | 21 | 10 | 4 | 3.20 | .256 | 1.01 | 7.0 | 2.1 | 4.3 | 149.0 | 116 | 53 | 53 | 16 | 34 | 72 | 3 | 0 | 0 | 1 | 13 | 4 | 2 | 4.19 |