| SP | Martinez, P.Martinez, Pedro † | Swords | R | 170.0 | 34 | 34 | 15 | 12 | 2.42 | .250 | 0.97 | 6.6 | 2.1 | 8.8 | 282.2 | 207 | 78 | 76 | 16 | 67 | 276 | 12 | 0 | 0 | 4 | 26 | 8 | 0 | 2.58 |
| SP | Leonard, D.Leonard, Dutch † | Swords | L | 146.0 | 32 | 32 | 16 | 8 | 2.50 | .252 | 1.00 | 6.2 | 2.8 | 5.2 | 237.2 | 163 | 72 | 66 | 10 | 74 | 137 | 3 | 0 | 0 | 3 | 25 | 3 | 4 | 3.37 |
| SP | Arrieta, J.Arrieta, Jake † | Cubbies | R | 145.0 | 36 | 36 | 20 | 9 | 3.33 | .291 | 1.23 | 8.2 | 2.8 | 8.7 | 235.0 | 214 | 96 | 87 | 23 | 74 | 227 | 2 | 0 | 0 | 0 | 27 | 1 | 6 | 3.30 |
| RP | Hendriks, L.Hendriks, Liam † | Sox | R | 137.5 | 100 | 0 | 23 | 2 | 3.98 | .293 | 1.23 | 8.9 | 2.1 | 10.7 | 120.0 | 119 | 56 | 53 | 17 | 28 | 143 | 0 | 1 | 0 | 0 | 0 | 2 | 3 | 3.21 |
| SP | Gilbert, L.Gilbert, Logan † | Mariners | R | 127.0 | 37 | 37 | 17 | 8 | 3.56 | .284 | 1.18 | 8.2 | 2.4 | 8.4 | 242.2 | 221 | 97 | 96 | 24 | 65 | 226 | 1 | 0 | 0 | 1 | 20 | 3 | 8 | 3.26 |
| SP | Santana, J.Santana, Johan # | Quadruplets | L | 123.0 | 36 | 36 | 17 | 8 | 3.89 | .291 | 1.22 | 8.1 | 2.9 | 8.3 | 252.0 | 227 | 111 | 109 | 25 | 80 | 232 | 3 | 0 | 0 | 1 | 21 | 4 | 8 | 3.45 |
| RP | Greene, S.Greene, Shane † | Cactus Kings | R | 123.0 | 101 | 0 | 15 | 3 | 3.11 | .269 | 1.08 | 7.1 | 2.6 | 8.7 | 124.1 | 98 | 49 | 43 | 9 | 36 | 120 | 0 | 8 | 1 | 0 | 0 | 3 | 0 | 2.95 |