| SP | Martinez, P.Martinez, Pedro † | Swords | R | 159.0 | 32 | 32 | 14 | 12 | 2.35 | .252 | 0.98 | 6.6 | 2.2 | 8.8 | 264.2 | 194 | 71 | 69 | 11 | 65 | 259 | 11 | 0 | 0 | 4 | 25 | 8 | 0 | 2.41 |
| SP | Arrieta, J.Arrieta, Jake † | Cubbies | R | 138.0 | 33 | 33 | 19 | 7 | 3.36 | .291 | 1.23 | 8.2 | 2.9 | 8.8 | 214.0 | 195 | 88 | 80 | 19 | 68 | 209 | 2 | 0 | 0 | 0 | 24 | 1 | 6 | 3.17 |
| SP | Leonard, D.Leonard, Dutch † | Swords | L | 136.0 | 31 | 31 | 15 | 8 | 2.59 | .253 | 1.00 | 6.2 | 2.8 | 5.1 | 229.1 | 158 | 72 | 66 | 10 | 72 | 131 | 3 | 0 | 0 | 3 | 24 | 3 | 4 | 3.41 |
| RP | Hendriks, L.Hendriks, Liam † | Sox | R | 125.5 | 88 | 0 | 21 | 2 | 3.95 | .295 | 1.23 | 9.0 | 2.1 | 10.9 | 107.0 | 107 | 50 | 47 | 16 | 25 | 129 | 0 | 1 | 0 | 0 | 0 | 2 | 3 | 3.29 |
| RP | Greene, S.Greene, Shane † | Cactus Kings | R | 121.0 | 92 | 0 | 14 | 3 | 2.68 | .257 | 1.01 | 6.6 | 2.5 | 8.6 | 114.0 | 83 | 40 | 34 | 7 | 32 | 109 | 0 | 8 | 1 | 0 | 0 | 3 | 0 | 2.81 |
| SP | Driscoll, D.Driscoll, Denny | Pir8tes | L | 116.0 | 30 | 30 | 17 | 9 | 3.97 | .282 | 1.16 | 9.1 | 1.3 | 4.7 | 220.0 | 223 | 108 | 97 | 24 | 32 | 115 | 13 | 0 | 0 | 2 | 15 | 4 | 0 | 3.86 |
| SP | Pineda, M.Pineda, Michael † | Mariners | R | 114.0 | 30 | 0 | 18 | 6 | 3.62 | .309 | 1.33 | 8.1 | 3.9 | 7.0 | 169.0 | 152 | 70 | 68 | 15 | 73 | 132 | 0 | 0 | 0 | 0 | 0 | 2 | 9 | 3.92 |