| SP | Martinez, P.Martinez, Pedro † | Swords | R | 159.0 | 32 | 32 | 14 | 12 | 2.35 | .252 | 0.98 | 6.6 | 2.2 | 8.8 | 264.2 | 194 | 71 | 69 | 11 | 65 | 259 | 11 | 0 | 0 | 4 | 25 | 8 | 0 | 2.41 |
| SP | Arrieta, J.Arrieta, Jake † | Cubbies | R | 137.0 | 32 | 32 | 19 | 7 | 3.39 | .289 | 1.22 | 8.2 | 2.7 | 8.9 | 207.0 | 189 | 84 | 78 | 19 | 63 | 204 | 2 | 0 | 0 | 0 | 23 | 1 | 6 | 3.15 |
| SP | Leonard, D.Leonard, Dutch † | Swords | L | 126.0 | 30 | 30 | 14 | 8 | 2.68 | .256 | 1.02 | 6.4 | 2.9 | 5.2 | 221.1 | 156 | 72 | 66 | 10 | 70 | 128 | 3 | 0 | 0 | 3 | 23 | 3 | 4 | 3.42 |
| RP | Hendriks, L.Hendriks, Liam † | Sox | R | 125.5 | 87 | 0 | 21 | 2 | 3.93 | .295 | 1.23 | 9.0 | 2.1 | 10.9 | 105.1 | 105 | 49 | 46 | 16 | 25 | 127 | 0 | 1 | 0 | 0 | 0 | 2 | 3 | 3.33 |
| SP | Driscoll, D.Driscoll, Denny | Pir8tes | L | 116.0 | 30 | 30 | 17 | 9 | 3.97 | .282 | 1.16 | 9.1 | 1.3 | 4.7 | 220.0 | 223 | 108 | 97 | 24 | 32 | 115 | 13 | 0 | 0 | 2 | 15 | 4 | 0 | 3.86 |
| RP | Greene, S.Greene, Shane † | Cactus Kings | R | 115.5 | 90 | 0 | 14 | 3 | 2.77 | .261 | 1.03 | 6.7 | 2.6 | 8.7 | 110.2 | 82 | 40 | 34 | 7 | 32 | 106 | 0 | 7 | 1 | 0 | 0 | 3 | 0 | 2.85 |
| SP | Pineda, M.Pineda, Michael † | Mariners | R | 114.0 | 30 | 0 | 18 | 6 | 3.62 | .309 | 1.33 | 8.1 | 3.9 | 7.0 | 169.0 | 152 | 70 | 68 | 15 | 73 | 132 | 0 | 0 | 0 | 0 | 0 | 2 | 9 | 3.92 |
| SP | Santana, J.Santana, Johan # | Quadruplets | L | 112.0 | 31 | 31 | 16 | 7 | 3.90 | .292 | 1.22 | 8.5 | 2.5 | 8.3 | 216.2 | 205 | 96 | 94 | 23 | 60 | 198 | 3 | 0 | 0 | 1 | 18 | 3 | 7 | 3.43 |