| SP | Chesbro, J.Chesbro, Jack † | Senators | R | 206.0 | 50 | 50 | 23 | 16 | 3.25 | .289 | 1.19 | 8.5 | 2.2 | 3.7 | 415.1 | 391 | 171 | 150 | 3 | 102 | 169 | 25 | 0 | 0 | 4 | 31 | 14 | 9 | 3.12 |
| SP | Nichols, K.Nichols, Kid † | Blues | R | 199.0 | 51 | 51 | 23 | 22 | 3.18 | .297 | 1.24 | 8.7 | 2.4 | 3.7 | 413.2 | 400 | 179 | 146 | 5 | 112 | 170 | 26 | 0 | 0 | 5 | 32 | 13 | 6 | 3.24 |
| SP | Tannehill, J.Tannehill, Jesse † | Americans | L | 166.0 | 54 | 54 | 21 | 25 | 3.54 | .307 | 1.30 | 9.7 | 1.9 | 3.9 | 435.1 | 470 | 231 | 171 | 2 | 94 | 189 | 23 | 0 | 0 | 3 | 32 | 15 | 15 | 2.94 |
| SP | Dinneen, B.Dinneen, Bill † | Tigers | R | 162.0 | 50 | 50 | 24 | 24 | 3.77 | .307 | 1.27 | 9.1 | 2.3 | 3.3 | 398.2 | 404 | 203 | 167 | 8 | 103 | 148 | 24 | 0 | 0 | 0 | 27 | 23 | 10 | 3.47 |
| SP | Townsend, H.Townsend, Happy | Athletics | R | 137.0 | 51 | 51 | 20 | 24 | 3.67 | .305 | 1.29 | 7.8 | 3.8 | 3.5 | 389.2 | 338 | 194 | 159 | 3 | 163 | 152 | 13 | 0 | 0 | 3 | 32 | 11 | 17 | 3.66 |
| SP | McGinnity, J.McGinnity, Joe | Athletics | R | 134.0 | 42 | 42 | 23 | 15 | 4.45 | .313 | 1.34 | 10.2 | 1.9 | 3.3 | 323.2 | 366 | 195 | 160 | 6 | 67 | 117 | 18 | 0 | 0 | 3 | 16 | 10 | 2 | 3.23 |