| SP | Greinke, Z.Greinke, Zack † | Homers | R | 164.0 | 35 | 35 | 22 | 12 | 3.31 | .270 | 1.08 | 7.4 | 2.3 | 4.9 | 258.2 | 213 | 96 | 95 | 28 | 66 | 140 | 13 | 0 | 0 | 6 | 24 | 8 | 9 | 4.19 |
| SP | deGrom, J.deGrom, Jacob † | Warriors | R | 154.0 | 34 | 34 | 18 | 8 | 2.60 | .274 | 1.11 | 7.0 | 3.0 | 9.8 | 221.1 | 172 | 69 | 64 | 17 | 74 | 240 | 1 | 0 | 0 | 1 | 28 | 5 | 0 | 2.90 |
| SP | Koufax, S.Koufax, Sandy † $$ | Seals | L | 148.0 | 36 | 36 | 16 | 10 | 2.69 | .278 | 1.11 | 7.3 | 2.7 | 8.3 | 234.0 | 189 | 74 | 70 | 17 | 70 | 216 | 8 | 0 | 0 | 2 | 19 | 11 | 4 | 3.14 |
| SP | Martinez, P.Martinez, Pedro † $$ | Brew Masters | R | 143.0 | 36 | 36 | 16 | 14 | 2.87 | .277 | 1.12 | 7.5 | 2.6 | 9.0 | 260.0 | 216 | 91 | 83 | 26 | 74 | 261 | 6 | 0 | 0 | 3 | 23 | 9 | 5 | 3.25 |
| SP | Scherzer, M.Scherzer, Max | Sloths | R | 127.0 | 34 | 34 | 16 | 11 | 3.09 | .299 | 1.26 | 7.8 | 3.5 | 8.8 | 232.2 | 201 | 85 | 80 | 22 | 91 | 226 | 2 | 0 | 0 | 1 | 26 | 6 | 4 | 3.54 |
| SP | Arrieta, J.Arrieta, Jake $ | Bombers | R | 126.0 | 34 | 34 | 17 | 7 | 3.32 | .271 | 1.10 | 7.1 | 2.8 | 7.3 | 209.0 | 166 | 78 | 77 | 19 | 64 | 169 | 2 | 0 | 0 | 0 | 23 | 3 | 4 | 3.53 |
| SP | Johnson, R.Johnson, Randy # | Warriors | L | 126.0 | 32 | 32 | 17 | 9 | 3.84 | .272 | 1.11 | 7.8 | 2.2 | 9.2 | 234.1 | 204 | 101 | 100 | 33 | 56 | 240 | 8 | 0 | 0 | 1 | 17 | 2 | 2 | 3.53 |