| SP | Koufax, S.Koufax, Sandy † | Tigers | L | 109.0 | 19 | 19 | 11 | 3 | 2.14 | .263 | 1.05 | 6.9 | 2.6 | 8.0 | 139.0 | 106 | 36 | 33 | 12 | 40 | 123 | 5 | 0 | 0 | 1 | 16 | 3 | 6 | 3.28 |
| SP | Kluber, C.Kluber, Corey † | Rain | R | 92.0 | 20 | 20 | 12 | 5 | 3.45 | .269 | 1.07 | 7.7 | 1.9 | 8.6 | 146.0 | 125 | 59 | 56 | 20 | 31 | 139 | 3 | 0 | 0 | 3 | 11 | 5 | 1 | 3.62 |
| SP | Martinez, P.Martinez, Pedro | Monster Magnet | R | 86.0 | 21 | 21 | 10 | 8 | 3.08 | .280 | 1.15 | 7.5 | 2.8 | 7.5 | 160.2 | 134 | 61 | 55 | 17 | 50 | 134 | 6 | 0 | 0 | 2 | 14 | 3 | 1 | 3.70 |
| SP | Kershaw, C.Kershaw, Clayton † | Foxes | L | 85.0 | 21 | 21 | 9 | 9 | 2.87 | .253 | 0.99 | 7.4 | 1.5 | 8.2 | 163.0 | 134 | 53 | 52 | 13 | 28 | 148 | 8 | 0 | 0 | 0 | 16 | 4 | 8 | 2.81 |
| CL | Doolittle, S.Doolittle, Sean † | Rain | L | 83.0 | 38 | 0 | 1 | 2 | 2.62 | .270 | 1.08 | 7.9 | 1.9 | 8.5 | 34.1 | 30 | 13 | 10 | 3 | 7 | 32 | 0 | 30 | 3 | 0 | 0 | 1 | 3 | 2.97 |
| SP | Verlander, J.Verlander, Justin † # | Rain | R | 80.0 | 21 | 21 | 10 | 9 | 2.80 | .265 | 1.07 | 7.3 | 2.3 | 9.5 | 141.1 | 115 | 51 | 44 | 9 | 36 | 149 | 2 | 0 | 0 | 0 | 16 | 2 | 3 | 2.52 |