| SP | Cole, G.Cole, Gerrit † $$ | Red Sox | R | 152.0 | 37 | 37 | 20 | 6 | 3.50 | .286 | 1.17 | 7.6 | 2.9 | 10.8 | 236.1 | 200 | 94 | 92 | 34 | 76 | 283 | 2 | 0 | 0 | 0 | 26 | 8 | 5 | 3.54 |
| SP | Verlander, J.Verlander, Justin † | Grasshoppers | R | 134.0 | 37 | 37 | 19 | 15 | 3.58 | .281 | 1.14 | 7.3 | 3.0 | 9.8 | 266.1 | 215 | 108 | 106 | 46 | 89 | 291 | 3 | 0 | 0 | 1 | 24 | 8 | 5 | 4.15 |
| SP | deGrom, J.deGrom, Jacob $$ | Suns | R | 123.0 | 35 | 35 | 17 | 11 | 3.70 | .277 | 1.12 | 8.1 | 2.0 | 8.8 | 248.1 | 224 | 103 | 102 | 31 | 55 | 243 | 4 | 0 | 0 | 1 | 24 | 7 | 3 | 3.42 |
| SP | Wainwright, A.Wainwright, Adam | Lake Serpents | R | 120.0 | 31 | 31 | 18 | 6 | 3.43 | .285 | 1.16 | 8.2 | 2.2 | 7.1 | 181.0 | 165 | 73 | 69 | 26 | 45 | 142 | 0 | 0 | 0 | 0 | 18 | 6 | 1 | 4.14 |
| SP | Scherzer, M.Scherzer, Max † | Lake Serpents | R | 114.0 | 35 | 35 | 16 | 13 | 3.55 | .291 | 1.21 | 7.8 | 3.2 | 9.4 | 238.1 | 205 | 102 | 94 | 28 | 84 | 249 | 2 | 0 | 0 | 0 | 22 | 4 | 4 | 3.55 |
| SP | Harvey, M.Harvey, Matt † $ | Mountain Lions | R | 107.0 | 33 | 33 | 14 | 10 | 3.46 | .293 | 1.22 | 8.4 | 2.6 | 8.9 | 226.1 | 210 | 93 | 87 | 19 | 65 | 223 | 1 | 0 | 0 | 0 | 24 | 6 | 2 | 3.06 |