| SP | deGrom, J.deGrom, Jacob † $ | Suns | R | 142.0 | 34 | 34 | 13 | 4 | 2.97 | .263 | 1.03 | 7.2 | 2.1 | 10.0 | 257.2 | 205 | 86 | 85 | 35 | 61 | 285 | 4 | 0 | 0 | 1 | 23 | 10 | 5 | 3.38 |
| CL | Doolittle, S.Doolittle, Sean † $$ | Athletics | L | 140.5 | 73 | 0 | 4 | 6 | 3.30 | .322 | 1.37 | 8.4 | 4.1 | 10.7 | 73.2 | 68 | 27 | 27 | 9 | 33 | 87 | 0 | 47 | 5 | 0 | 0 | 4 | 1 | 3.74 |
| SP | Scherzer, M.Scherzer, Max † | Ducks | R | 132.0 | 34 | 34 | 13 | 10 | 2.82 | .274 | 1.12 | 7.3 | 2.8 | 10.2 | 245.1 | 199 | 79 | 77 | 25 | 75 | 277 | 5 | 0 | 0 | 0 | 27 | 4 | 2 | 3.03 |
| CL | Betances, D.Betances, Dellin † | Mountain Lions | R | 125.5 | 63 | 0 | 8 | 7 | 1.80 | .274 | 1.11 | 5.8 | 4.2 | 9.1 | 75.0 | 48 | 15 | 15 | 6 | 35 | 76 | 0 | 27 | 0 | 0 | 0 | 2 | 1 | 3.49 |
| SP | Verlander, J.Verlander, Justin $$ | Cyruses | R | 118.0 | 34 | 34 | 17 | 8 | 3.87 | .294 | 1.21 | 8.0 | 2.9 | 10.3 | 227.2 | 203 | 105 | 98 | 32 | 72 | 259 | 0 | 0 | 0 | 0 | 23 | 9 | 6 | 3.62 |
| CL | Kimbrel, C.Kimbrel, Craig # | Red Sox | R | 114.0 | 67 | 0 | 7 | 9 | 3.86 | .305 | 1.29 | 8.1 | 3.5 | 12.6 | 70.0 | 63 | 30 | 30 | 10 | 27 | 98 | 0 | 34 | 4 | 0 | 0 | 2 | 4 | 3.30 |
| SP | Kluber, C.Kluber, Corey $$ | Athletics | R | 112.0 | 34 | 34 | 17 | 8 | 4.01 | .277 | 1.11 | 7.4 | 2.6 | 9.7 | 206.1 | 170 | 94 | 92 | 32 | 60 | 223 | 2 | 0 | 0 | 1 | 20 | 7 | 5 | 3.83 |
| CL | Jansen, K.Jansen, Kenley † # | Suns | R | 109.5 | 66 | 0 | 7 | 8 | 4.48 | .282 | 1.14 | 7.7 | 2.6 | 9.4 | 70.1 | 60 | 37 | 35 | 11 | 20 | 73 | 0 | 35 | 6 | 0 | 0 | 3 | 4 | 3.94 |