| SP | Johnson, R.Johnson, Randy † $$ | Pirates | L | 118.5 | 19 | 18 | 14 | 2 | 2.69 | .266 | 1.06 | 7.6 | 2.0 | 8.5 | 137.1 | 115 | 43 | 41 | 16 | 30 | 130 | 5 | 1 | 0 | 0 | 13 | 4 | 0 | 3.36 |
| SP | Martinez, P.Martinez, Pedro † $ | Natives | R | 99.0 | 18 | 18 | 12 | 1 | 2.84 | .271 | 1.08 | 7.6 | 2.1 | 8.5 | 126.2 | 107 | 40 | 40 | 9 | 30 | 119 | 2 | 0 | 0 | 0 | 15 | 4 | 3 | 2.85 |
| CL | Wagner, B.Wagner, Billy † | Natives | L | 84.5 | 42 | 0 | 3 | 2 | 2.09 | .271 | 1.05 | 5.0 | 4.4 | 10.9 | 43.0 | 24 | 11 | 10 | 2 | 21 | 52 | 0 | 23 | 1 | 0 | 0 | 3 | 0 | 2.86 |
| SP | deGrom, J.deGrom, Jacob † | Pirates | R | 82.0 | 18 | 18 | 7 | 2 | 2.05 | .263 | 1.04 | 6.3 | 3.1 | 10.0 | 122.2 | 86 | 28 | 28 | 13 | 42 | 136 | 1 | 0 | 0 | 0 | 15 | 3 | 0 | 3.26 |
| SP | Scherzer, M.Scherzer, Max $ | Naps | R | 76.0 | 18 | 18 | 9 | 5 | 3.16 | .296 | 1.23 | 7.1 | 4.0 | 9.4 | 134.0 | 106 | 56 | 47 | 19 | 59 | 140 | 2 | 0 | 0 | 1 | 11 | 4 | 0 | 4.16 |
| SP | Schmidt, J.Schmidt, Jason | Natives | R | 69.0 | 17 | 17 | 9 | 5 | 3.38 | .289 | 1.21 | 8.2 | 2.8 | 8.0 | 117.0 | 106 | 47 | 44 | 14 | 36 | 104 | 3 | 0 | 0 | 2 | 11 | 1 | 2 | 3.73 |