| SP | Verlander, J.Verlander, Justin # | Nightmares | R | 134.0 | 35 | 35 | 18 | 9 | 3.80 | .265 | 1.05 | 7.7 | 1.8 | 10.9 | 249.0 | 213 | 105 | 105 | 40 | 49 | 302 | 3 | 0 | 0 | 1 | 22 | 8 | 6 | 3.35 |
| SP | Harvey, M.Harvey, Matt $$ | Red Sox | R | 132.0 | 32 | 32 | 18 | 9 | 3.40 | .288 | 1.20 | 8.3 | 2.5 | 9.4 | 217.0 | 199 | 86 | 82 | 29 | 61 | 227 | 3 | 0 | 0 | 1 | 22 | 3 | 3 | 3.53 |
| SP | Kluber, C.Kluber, Corey # $$ | Red Sox | R | 123.0 | 34 | 34 | 17 | 9 | 3.71 | .278 | 1.15 | 8.2 | 2.1 | 11.6 | 216.0 | 197 | 93 | 89 | 25 | 51 | 278 | 1 | 0 | 0 | 1 | 20 | 2 | 3 | 2.67 |
| CL | Benoit, J.Benoit, Joaquin † $$ | Panthers | R | 119.5 | 76 | 0 | 3 | 3 | 2.46 | .261 | 1.05 | 6.4 | 3.0 | 10.2 | 84.0 | 60 | 23 | 23 | 9 | 28 | 95 | 0 | 35 | 7 | 0 | 0 | 1 | 1 | 3.17 |
| SP | Hudson, D.Hudson, Daniel # | Boys | R | 118.0 | 33 | 33 | 17 | 9 | 3.75 | .289 | 1.20 | 8.1 | 2.7 | 8.0 | 232.2 | 210 | 104 | 97 | 28 | 69 | 206 | 2 | 0 | 0 | 1 | 21 | 5 | 4 | 3.75 |
| SP | Kershaw, C.Kershaw, Clayton | Ants | L | 116.0 | 34 | 34 | 17 | 13 | 3.91 | .288 | 1.17 | 8.8 | 1.7 | 9.3 | 235.0 | 230 | 116 | 102 | 36 | 44 | 243 | 7 | 0 | 0 | 2 | 19 | 11 | 3 | 3.63 |
| CL | Leclerc, J.Leclerc, Jose † | Pounders | R | 115.5 | 71 | 0 | 2 | 5 | 3.25 | .260 | 1.03 | 5.1 | 4.1 | 10.9 | 72.0 | 41 | 27 | 26 | 4 | 33 | 87 | 0 | 39 | 3 | 0 | 0 | 2 | 3 | 2.76 |
| CL | Betances, D.Betances, Dellin # | Red Sox | R | 114.0 | 61 | 0 | 2 | 6 | 4.40 | .299 | 1.26 | 7.8 | 3.7 | 11.4 | 59.1 | 51 | 29 | 29 | 10 | 24 | 75 | 0 | 44 | 3 | 0 | 0 | 1 | 2 | 3.93 |
| SP | deGrom, J.deGrom, Jacob † $$ | Boys | R | 111.0 | 35 | 35 | 16 | 14 | 3.82 | .296 | 1.19 | 8.2 | 2.5 | 10.2 | 242.2 | 221 | 104 | 103 | 21 | 68 | 275 | 4 | 0 | 0 | 2 | 20 | 17 | 4 | 2.91 |
| CL | Doolittle, S.Doolittle, Sean † | Friars | L | 109.5 | 63 | 0 | 4 | 5 | 3.18 | .242 | 0.94 | 5.4 | 3.0 | 11.8 | 68.0 | 41 | 26 | 24 | 10 | 23 | 89 | 0 | 33 | 3 | 0 | 0 | 1 | 3 | 3.35 |