| SP | Greinke, Z.Greinke, Zack † | Mustangs | R | 121.0 | 22 | 22 | 14 | 3 | 2.68 | .274 | 1.11 | 7.2 | 2.8 | 6.9 | 161.1 | 129 | 50 | 48 | 7 | 50 | 123 | 4 | 0 | 0 | 2 | 17 | 4 | 2 | 3.04 |
| SP | Maddux, G.Maddux, Greg † $$ | Mustangs | R | 114.0 | 23 | 23 | 15 | 6 | 3.09 | .275 | 1.11 | 8.1 | 1.9 | 6.0 | 172.0 | 154 | 62 | 59 | 12 | 37 | 114 | 4 | 0 | 0 | 2 | 14 | 5 | 5 | 3.31 |
| SP | Hunter, C.Hunter, Catfish # | Suns | R | 101.0 | 22 | 22 | 11 | 8 | 2.96 | .255 | 1.01 | 7.3 | 1.8 | 6.2 | 176.1 | 143 | 62 | 58 | 20 | 35 | 122 | 10 | 0 | 0 | 3 | 16 | 3 | 3 | 3.74 |
| SP | Martinez, P.Martinez, Pedro | Nightmares | R | 96.0 | 23 | 23 | 11 | 3 | 3.54 | .259 | 1.03 | 7.2 | 2.0 | 9.7 | 168.0 | 135 | 67 | 66 | 20 | 38 | 181 | 4 | 0 | 0 | 1 | 17 | 3 | 3 | 3.13 |
| SP | McClanahan, S.McClanahan, Shane † | El Trains | L | 94.0 | 22 | 22 | 12 | 5 | 2.88 | .282 | 1.15 | 7.5 | 2.9 | 9.7 | 137.1 | 114 | 47 | 44 | 13 | 44 | 148 | 0 | 0 | 0 | 0 | 14 | 4 | 3 | 3.12 |
| SP | deGrom, J.deGrom, Jacob $ | Middlemen | R | 92.0 | 21 | 21 | 10 | 4 | 2.66 | .271 | 1.10 | 7.8 | 2.2 | 10.0 | 142.1 | 123 | 50 | 42 | 12 | 34 | 157 | 1 | 0 | 0 | 0 | 14 | 2 | 0 | 2.65 |
| SP | Kershaw, C.Kershaw, Clayton # | Reapers | L | 89.0 | 23 | 23 | 9 | 8 | 3.01 | .275 | 1.11 | 8.2 | 1.8 | 8.9 | 176.1 | 161 | 62 | 59 | 24 | 35 | 175 | 7 | 0 | 0 | 1 | 17 | 5 | 5 | 3.47 |
| SP | Arrieta, J.Arrieta, Jake † $ | Middlemen | R | 84.0 | 22 | 22 | 11 | 6 | 3.48 | .290 | 1.22 | 8.0 | 3.1 | 8.5 | 165.2 | 146 | 69 | 64 | 19 | 56 | 155 | 2 | 0 | 0 | 0 | 12 | 1 | 1 | 3.65 |