| SP | Koufax, S.Koufax, Sandy † $$ | Blue | L | 168.0 | 27 | 27 | 15 | 9 | 2.26 | .233 | 0.89 | 6.0 | 2.0 | 8.3 | 231.0 | 154 | 58 | 58 | 13 | 51 | 212 | 19 | 0 | 0 | 5 | 23 | 5 | 3 | 2.62 |
| SP | Fernandez, S.Fernandez, Sid † | Eskimos | L | 147.0 | 26 | 25 | 18 | 5 | 2.25 | .276 | 1.14 | 6.4 | 3.8 | 6.8 | 179.2 | 128 | 49 | 45 | 11 | 76 | 135 | 2 | 0 | 0 | 0 | 22 | 1 | 7 | 3.58 |
| SP | deGrom, J.deGrom, Jacob † $$ | Royals | R | 128.0 | 27 | 27 | 15 | 4 | 2.73 | .280 | 1.16 | 7.7 | 2.7 | 9.5 | 181.1 | 155 | 58 | 55 | 12 | 55 | 191 | 1 | 0 | 0 | 0 | 19 | 2 | 0 | 2.70 |
| SP | Leonard, D.Leonard, Dutch | Royals | L | 124.0 | 26 | 26 | 15 | 4 | 2.50 | .282 | 1.16 | 7.4 | 3.0 | 5.4 | 176.1 | 145 | 55 | 49 | 8 | 59 | 106 | 1 | 0 | 0 | 0 | 18 | 4 | 3 | 3.46 |
| SP | Richard, J.Richard, J.R. $ | Royals | R | 109.0 | 27 | 27 | 13 | 7 | 2.71 | .261 | 1.05 | 6.3 | 3.2 | 7.4 | 182.1 | 128 | 59 | 55 | 11 | 64 | 150 | 0 | 0 | 0 | 0 | 19 | 1 | 1 | 3.21 |
| SP | Hunter, C.Hunter, Catfish | Blue | R | 101.0 | 26 | 26 | 14 | 3 | 3.29 | .288 | 1.20 | 7.3 | 3.5 | 4.4 | 169.2 | 138 | 71 | 62 | 15 | 65 | 82 | 0 | 0 | 0 | 0 | 17 | 3 | 3 | 4.39 |
| SP | Alexander, P.Alexander, Pete | Blue | R | 98.0 | 26 | 26 | 13 | 6 | 3.22 | .266 | 1.07 | 7.3 | 2.4 | 4.8 | 176.0 | 143 | 72 | 63 | 19 | 46 | 94 | 2 | 0 | 0 | 2 | 18 | 2 | 5 | 4.15 |
| SP | Maddux, G.Maddux, Greg † $ | Blue | R | 97.0 | 26 | 26 | 13 | 7 | 3.45 | .273 | 1.12 | 8.4 | 1.7 | 4.7 | 198.0 | 184 | 79 | 76 | 13 | 37 | 104 | 3 | 0 | 0 | 1 | 19 | 2 | 2 | 3.39 |