| SP | Martinez, P.Martinez, Pedro † | Wolves | R | 202.0 | 36 | 36 | 21 | 8 | 2.53 | .262 | 1.04 | 7.5 | 1.8 | 9.8 | 278.0 | 232 | 91 | 78 | 30 | 57 | 303 | 10 | 0 | 0 | 2 | 28 | 7 | 3 | 2.91 |
| SP | Johnson, R.Johnson, Randy † | Banditos | L | 152.0 | 34 | 34 | 21 | 8 | 3.52 | .280 | 1.13 | 7.3 | 2.9 | 10.2 | 238.0 | 194 | 97 | 93 | 26 | 76 | 271 | 2 | 0 | 0 | 0 | 24 | 7 | 8 | 3.19 |
| SP | Schilling, C.Schilling, Curt † # | Americans | R | 142.0 | 35 | 35 | 19 | 11 | 3.52 | .280 | 1.12 | 8.0 | 2.1 | 9.1 | 243.0 | 216 | 97 | 95 | 31 | 57 | 246 | 7 | 0 | 0 | 2 | 21 | 10 | 4 | 3.46 |
| CL | Papelbon, J.Papelbon, Jonathan † | Bulls | R | 141.0 | 87 | 0 | 9 | 6 | 2.99 | .262 | 1.02 | 6.9 | 2.3 | 9.4 | 105.1 | 80 | 36 | 35 | 17 | 27 | 110 | 0 | 32 | 4 | 0 | 0 | 5 | 1 | 3.92 |
| SP | Hernandez, F.Hernandez, Felix † | Devils | R | 124.0 | 35 | 35 | 18 | 12 | 3.80 | .296 | 1.23 | 7.7 | 3.3 | 6.9 | 248.2 | 213 | 108 | 105 | 28 | 92 | 191 | 9 | 0 | 0 | 2 | 18 | 8 | 6 | 4.14 |
| RP | Soriano, R.Soriano, Rafael | Mustangs | R | 118.5 | 90 | 0 | 12 | 3 | 2.57 | .251 | 0.98 | 6.4 | 2.4 | 9.1 | 133.1 | 94 | 41 | 38 | 6 | 36 | 134 | 0 | 9 | 4 | 0 | 0 | 4 | 0 | 2.47 |
| CL | Benitez, A.Benitez, Armando † | Slammers | R | 116.5 | 75 | 0 | 3 | 4 | 2.58 | .288 | 1.20 | 5.9 | 5.0 | 5.7 | 76.2 | 50 | 25 | 22 | 5 | 42 | 48 | 0 | 37 | 7 | 0 | 0 | 1 | 0 | 4.29 |