| CL | Benoit, J.Benoit, Joaquin | Pirates | R | 143.0 | 67 | 0 | 4 | 4 | 2.75 | .273 | 1.07 | 6.5 | 3.1 | 9.6 | 72.0 | 52 | 22 | 22 | 4 | 25 | 77 | 0 | 44 | 3 | 0 | 0 | 4 | 0 | 2.79 |
| SP | Verlander, J.Verlander, Justin | Lions | R | 141.0 | 35 | 35 | 18 | 9 | 3.22 | .278 | 1.13 | 7.7 | 2.5 | 9.2 | 240.2 | 204 | 90 | 86 | 32 | 67 | 246 | 2 | 0 | 0 | 0 | 25 | 7 | 1 | 3.61 |
| CL | Chapman, A.Chapman, Aroldis | Alamos | L | 140.0 | 58 | 0 | 8 | 3 | 1.99 | .248 | 0.99 | 5.0 | 4.0 | 11.9 | 58.2 | 32 | 13 | 13 | 1 | 26 | 77 | 0 | 34 | 4 | 0 | 0 | 0 | 1 | 1.91 |
| SP | Kershaw, C.Kershaw, Clayton † | Pirates | L | 139.0 | 35 | 35 | 18 | 11 | 3.49 | .263 | 1.02 | 7.7 | 1.5 | 9.6 | 260.1 | 223 | 101 | 101 | 33 | 43 | 276 | 5 | 0 | 0 | 0 | 25 | 12 | 6 | 3.16 |
| SP | Fernandez, J.Fernandez, Jose # | Sharks | R | 133.0 | 34 | 34 | 17 | 10 | 3.03 | .298 | 1.24 | 7.2 | 3.9 | 9.9 | 220.0 | 177 | 75 | 74 | 21 | 95 | 242 | 0 | 0 | 0 | 0 | 25 | 8 | 3 | 3.45 |
| SP | Scherzer, M.Scherzer, Max † | Aces | R | 127.0 | 34 | 34 | 14 | 8 | 3.09 | .297 | 1.23 | 7.3 | 3.7 | 10.2 | 233.0 | 190 | 88 | 80 | 20 | 97 | 265 | 2 | 0 | 0 | 0 | 23 | 8 | 3 | 3.19 |